Carbamazepine solubility enhancement in tandem with swellable polymer osmotic pump tablet: A promising approach for extended delivery of poorly water-soluble drugs

Rabti, Hadjira; Salmani, Jumah Masoud M; Elamin, Eltayeb S.; Lammari, Narimane; Zhang, Jie; Ping, Qineng

doi:10.1016/j.ajps.2014.04.001

Cited by 13 publications

(7 citation statements)

References 18 publications

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“…Additionally, it is also worth mentioning that the Taguchi array is an experimental design that is already used in pharmaceutical technology to support the development of controlled release formulations, for example, in the evaluation of process and formulation variables in the development of a gastroretentive rivastigmine system [ 19 ], the development and optimization of solid lipid nanoparticles of isradipine [ 20 ], and in the production of carbamazepine [ 21 ] and cilostazol [ 22 ] osmotic pumps.…”

Section: Resultsmentioning

confidence: 99%

Development of Biopredictive Dissolution Method for Extended-Release Desvenlafaxine Tablets

Carapeto,

Duque,

Issa

et al. 2023

Pharmaceutics

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This study aimed to develop a biopredictive dissolution method for desvenlafaxine ER tablets using design of experiments (DoE) and physiologically based biopharmaceutics modeling (PBBM) to address the challenge of developing generic drug products by reducing the risk of product failure in pivotal bioequivalence studies. For this purpose, a PBBM was developed in GastroPlus® and combined with a Taguchi L9 design, to evaluate the impact of different drug products (Reference, Generic #1 and Generic #2) and dissolution test conditions on desvenlafaxine release. The influence of the superficial area/volume ratio (SA/V) of the tablets was observed, mainly for Generic #1, which presented higher SA/V than the others, and a high amount of drug dissolved under similar test conditions. The dissolution test conditions of 900 mL of 0.9% NaCl and paddle at 50 rpm with sinker showed to be biopredictive, as it was possible to demonstrate virtual bioequivalence for all products, despite their release-pattern differences, including Generic #3 as an external validation. This approach led to a rational development of a biopredictive dissolution method for desvenlafaxine ER tablets, providing knowledge that may help the process of drug product and dissolution method development.

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Section: Resultsmentioning

confidence: 99%

Development of Biopredictive Dissolution Method for Extended-Release Desvenlafaxine Tablets

Carapeto,

Duque,

Issa

et al. 2023

Pharmaceutics

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“…[38,39] Researchers have attempted several different formulations to increase the water solubility of CBZ, including quick release pellets, [40] solid dispersions, [41] and tablets. [42] Some researchers have also tried to alter physicochemical charac-teristics using a crystal engineering technique. [43] Several reports on the synthesis of CBZ cocrystals [34] are available in the literature, however very few reports on the improvement of CBZ's dissolution (Table 4).…”

Section: Solubility/dissolution Ratementioning

confidence: 99%

Advances in Carbamazepine Cocrystals: A Review

Kalantri,

Yadav

2024

Cryst. Res. Technol.

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Carbamazepine (CBZ), a widely used antiepileptic drug, is known for its therapeutic efficacy but exhibits suboptimal physicochemical characteristics, including limited bioavailability, low solubility, and poor dissolution rates. In recent years, cocrystallization has emerged as a promising approach to improve these properties and enhance the overall performance of CBZ. This review paper presents a comprehensive exploration of the advances in CBZ cocrystals, focusing on their role in enhancing bioavailability, solubility/dissolution rates, morphology, and stability compared to raw CBZ. It delves into the in‐depth examination of computational techniques, such as molecular modelling and crystal structure prediction, that play a pivotal role in the rational design and prediction of CBZ cocrystals, thereby expediting the development process. Additionally, the morphological attributes of CBZ cocrystals are discussed, shedding light on how the unique crystal structures affect their physical properties. Stability is another critical aspect addressed in this review, encompassing thermal, physical, and chemical stability. The thermal behavior of CBZ cocrystals is analyzed through differential scanning calorimetry (DSC), and their crystal structures are characterized by techniques such as X‐ray diffraction (XRD) and Fourier‐transform infrared spectroscopy (FTIR). These analyses reveal the stability and structural changes of CBZ cocrystals under various conditions, providing valuable insights for formulation and storage. In summary, this comprehensive review paper amalgamates the latest advancements in CBZ cocrystals, demonstrating their capacity to significantly improve bioavailability, solubility, dissolution rates, and stability.

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“…In aquatic environments, the amount of pharmaceuticals can be minimized using a unique sustained-release drug delivery system based on osmosis, known as the elemental osmotic pump [ 15 ]. To remove diclofenac, the authors of [ 16 ] used sulfur-doped TiO 2 (S-TiO 2 ) compounds with reduced graphene oxide (rGO) and a weight percentage of rGO.…”

Section: Introductionmentioning

confidence: 99%

The Importance of Humic Substances in Transporting “Chemicals of Emerging Concern” in Water and Sewage Environments

Anielak,

Styszko,

Kwaśny

2023

Molecules

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In this study, we examined the sorption of selected “chemicals of emerging concern” (CEC) on humic substances commonly found in water and municipal wastewater. These were ibuprofen, diclofenac, caffeine, carbamazepine, estrone, triclosan, bisphenol A, and isoproturon. The humic substances (HSs) were synthetic and not contaminated by the tested organic substances. The elemental composition and content of mineral micropollutants, gravimetric curves, and the IR spectrum of HSs were determined. We determined a relationship between the process efficiency and the characteristics of a sorbent and sorbate using the properties of organic substances sorbed on HSs. This relationship was confirmed by sorption tests on the HS complex, i.e., the HS-organic micropollutant. It has been shown that the given complexes have a greater affinity for hydrophobic surfaces than hydrophilic surfaces. To confirm the nature of the sorbent surfaces, we determined their zeta potential dependence on the pH of the solution. Studies have shown that HSs are carriers of both mineral substances and CEC in water and sewage environments.

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Carbamazepine solubility enhancement in tandem with swellable polymer osmotic pump tablet: A promising approach for extended delivery of poorly water-soluble drugs

Cited by 13 publications

References 18 publications

Development of Biopredictive Dissolution Method for Extended-Release Desvenlafaxine Tablets

Development of Biopredictive Dissolution Method for Extended-Release Desvenlafaxine Tablets

Advances in Carbamazepine Cocrystals: A Review

The Importance of Humic Substances in Transporting “Chemicals of Emerging Concern” in Water and Sewage Environments

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