Carbapenem-resistance worldwide: a call for action – correspondence

Mohd, Ahmed B; Huneiti, Nesreen; Hasan, Hanan; Mohd, Omar B; Khaity, Abdulrhman; Albakri, Khaled

doi:10.1097/ms9.0000000000000262

Cited by 2 publications

(1 citation statement)

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“…This highlights the potential risk of transmission and the challenges in treating patients who acquire infections caused by these MDR bacteria transmitted through the hospital environment [17,34,35]. Of particular concern is the presence of the acquired blaNDM gene in this study, which encodes the New Delhi metallo-beta-lactamase and confers resistance to many beta-lactam antibiotics, including carbapenems, the last-resort antibiotics used to treat severe MDR bacterial infections [36]. It is worth noting that the acquired blaNDM gene can be horizontally transferred to other bacteria in the environment, further contributing to the dissemination of drug resistance [37][38][39].…”

Section: Discussionmentioning

confidence: 98%

Hospital Wastes as Potential Sources for Multi-Drug-Resistant ESBL-Producing Bacteria at a Tertiary Hospital in Ethiopia

Gashaw,

Gudina,

Tadesse

et al. 2024

Antibiotics

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The hospital environment is increasingly becoming an important reservoir for multi-drug-resistant (MDR) Gram-negative bacteria, posing serious challenges to efforts to combat antimicrobial resistance (AMR). This study aimed to investigate the role of hospital waste as a potential source of MDR ESBL-producing bacteria. Samples were collected from multiple sources within a hospital and its vicinity, including surface swabs, houseflies, and sewage samples. The samples were subsequently processed in a microbiology laboratory to identify potential pathogenic bacteria and confirmed using MALDI-TOF MS. Bacteria were isolated from 87% of samples, with the predominant isolates being E. coli (30.5%), Klebsiella spp. (12.4%), Providencia spp. (12.4%), and Proteus spp. (11.9%). According to the double disc synergy test (DDST) analysis, nearly half (49.2%) of the bacteria were identified as ESBL producers. However, despite exhibiting complete resistance to beta-lactam antibiotics, 11.8% of them did not test positive for ESBL production. The characterization of E. coli revealed that 30.6% and 5.6% of them carried blaCTX-M group 1 type-15 and blaNDM genes, respectively. This finding emphasizes the importance of proper hospital sanitation and waste management practices to mitigate the spread of AMR within the healthcare setting and safeguard the health of both patients and the wider community.

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