Carbapenem-resistant Acinetobacter baumannii (CRAB) Recovered from Burn Patients

Adibhesami, Habibeh; Douraghi, Masoumeh; Zeraati, Hojjat; F, Bazmi; Rahbar, Mohammad; Pourmand, Mohammad Reza; Tabrizi, Mahboobeh Satarzadeh; Aliramezani, Amir; Ghourchian, Sedigheh

doi:10.18433/j3qk6m

Cited by 9 publications

(4 citation statements)

References 29 publications

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“… 104 , 116 , 117 Colistin, an old antibiotic discontinued because of its nephrotoxicity, has re-emerged as an useful agent in the treatment of infections caused by MDRO. 118 , 119 However, due to the use of colistin, the appearance of colistin-resistant organisms is worrisome, as available therapeutic options seem scarce; some studies have reported the usefulness of combination therapy (eg, colistin, amikacin, tigecycline) in the treatment of colistin-resistant infections. 120 , 121 Early consultation of infectious diseases specialists is advocated in challenging cases.…”

Section: Management Of Sepsis In Burn Patientsmentioning

confidence: 99%

Predicting and managing sepsis in burn patients: current perspectives

Lopez¹,

Cambiaso‐Daniel²,

Branski³

et al. 2017

TCRM

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Modern burn care has led to unprecedented survival rates in burn patients whose injuries were fatal a few decades ago. Along with improved survival, new challenges have emerged in the management of burn patients. Infections top the list of the most common complication after burns, and sepsis is the leading cause of death in both adult and pediatric burn patients. The diagnosis and management of sepsis in burns is complex as a tremendous hypermetabolic response secondary to burn injury can be superimposed on systemic infection, leading to organ dysfunction. The management of a septic burn patient represents a challenging scenario that is commonly encountered by providers caring for burn patients despite preventive efforts. Here, we discuss the current perspectives in the diagnosis and treatment of sepsis and septic shock in burn patients.

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Section: Management Of Sepsis In Burn Patientsmentioning

confidence: 99%

Predicting and managing sepsis in burn patients: current perspectives

Lopez¹,

Cambiaso‐Daniel²,

Branski³

et al. 2017

TCRM

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“… [ 30 ] A. baumanii n.r. Iran [ 31 – 41 ] A. baumanii KPC&VIM&OXA-23; VIM&OXA-23; KPC&OXA-23; OXA-23; OXA-40; OXA-23&OXA-40; OXA-23&OXA-58; OXA-23&OXA-40&OXA-58; OXA-40&OXA-58; OXA-23&OXA-58; OXA-143; OXA-58; OXA-23&OXA-24; OXA-24; KPC; VIM [ 41 – 47 ] P. aeruginosa IMP&VIM; IMP; VIM; KPC; AIM [ 41 , 48 , 49 ] K. pneumoniae KPC Israël [ 7 ] P. aeruginosa n.r. [ 7 ] A. baumanii n.r.…”

Section: Resultsmentioning

confidence: 99%

Extensive colonization with carbapenemase-producing microorganisms in Romanian burn patients: infectious consequences from the Colectiv fire disaster

Pirii

Friedrich

Rossen

et al. 2017

Eur J Clin Microbiol Infect Dis

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Health care of severe burn patients is highly specialized and may require international patient transfer. Burn patients have an increased risk of developing infections. Patients that have been hospitalized in countries where carbapenemase-producing microorganisms (CPMO) are endemic may develop infections that are difficult to treat. In addition, there is a risk on outbreaks with CPMOs in burn centers. This study underlines that burn patients may extensively be colonized with CPMOs, and it provides best practice recommendations regarding clinical microbiology and infection control. We evaluated CPMO-carriage and wound colonization in a burn patient initially treated in Romania, and transported to the Netherlands. The sequence types and acquired beta-lactamase genes of highly-resistant microorganisms were derived from next generation sequencing data. Next, we searched literature for reports on CPMOs in burn patients. Five different carbapenemase-producing isolates were cultured: two unrelated OXA-48-producing Klebsiella pneumoniae isolates, OXA-23-producing Acinetobacter baumanii, OXA-48-producing Enterobacter cloacae, and NDM-1-producing Providencia stuartii. Also, multi-drug resistant Pseudomonas aeruginosa isolates were detected. Among the sampling sites, there was high variety in CPMOs. We found 46 reports on CPMOs in burn patients. We listed the epidemiology of CPMOs by country of initial treatment, and summarized recommendations for care of these patients based on these reports and our study.

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“…Частота гнійно-запальних захворювань, спричинених цими мікроорганізмами, збільшується в усьому світі [19]. Справжнім лихом ці мікроорганізми стали для хірургічних і комбустіологічних відділень лікувальних установ [1,17]. Двоє представників цих родів (P. aeruginosa та A. baumannii) у лютому 2017 р. Всесвітньою організацією охорони здоров'я внесено у список "пріо-ритетних патогенів", що несуть найбільшу загрозу для здоров'я людини [8].…”

Section: вступunclassified

Study of the influence of individual components in the cultivation environment on P. aeruginosa and A. baumannii biofilm-forming activity

Kovalchuk¹,

Burkot²,

Dudar³

et al. 2023

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. P. aeruginosa, A. baumannii are the causative agents of severe wound infections, ventilator-associated pneumonia, catheter-associated septic conditions and other severe pathological processes. The ability of bacteria to form biofilms in affected tissues plays an important role in the pathogenesis of these diseases. Therefore, the purpose of our work is to study the influence of certain external factors on the ability of bacteria to form biofilms. The ability of bacteria to form biofilms in affected tissues plays an important role in the pathogenesis of these diseases. 5 clinical strains of P. aeruginosa and 5 strains of A. baumannii were used in this research. The ability to form biofilms was studied in 96-well polystyrene plates by the spectrophotometric method, which is based on the ability of the crystal violet dye to bind to the cells and matrix of the biofilm. Statistical processing of the obtained results was carried out using Excel Microsoft Office tables. The effect of the presence of certain sugars and nitrogen-containing compounds in the cultivation medium on the processes of biofilm formation by pseudomonads and acinetobacteria was investigated. As a result of the research, it was established that acinetobacteria show the ability to form films, unlike pseudomonads, under the condition of their cultivation in sterile distilled water. The introduction of certain carbohydrates or urea into the cultivation medium intensified the biofilm-forming properties of pseudomonads to a much greater extent, compared to acinetobacteria. According to the research results, it was established that the most active process of biofilm formation occurs in both types of non-fermenting Gram-negative bacteria when there are animal blood serum proteins in the culture medium. The formation of biofilms is one of the main strategies that increases the survival of bacteria in the environment, as well as in the human body. The ability of bacteria to form biofilms is, among other things, a factor in the pathogenicity and virulence of bacteria. So, in recent years, special attention has been paid to the ability of microorganisms to form biofilms, and to the study of factors affecting this process.

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Carbapenem-resistant Acinetobacter baumannii (CRAB) Recovered from Burn Patients

Abstract: -Purpose. Emergence of carbapenem-resistant Acinetobacter baumannii (CRAB) and their prolonged presence in burn units increases the risk of acquisition of CRAB. Methods. From

Cited by 9 publications

References 29 publications

Predicting and managing sepsis in burn patients: current perspectives

Predicting and managing sepsis in burn patients: current perspectives

Extensive colonization with carbapenemase-producing microorganisms in Romanian burn patients: infectious consequences from the Colectiv fire disaster

Study of the influence of individual components in the cultivation environment on P. aeruginosa and A. baumannii biofilm-forming activity

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