2016
DOI: 10.1128/jcm.03264-15
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Carbapenem-Resistant Non-Glucose-Fermenting Gram-Negative Bacilli: the Missing Piece to the Puzzle

Abstract: The non-glucose-fermenting Gram-negative bacilli Pseudomonas aeruginosa and Acinetobacter baumannii are increasingly acquiring carbapenem resistance. Given their intrinsic antibiotic resistance, this can cause extremely difficult-to-treat infections. Additionally, resistance gene transfer can occur between Gram-negative species, regardless of their ability to ferment glucose. Thus, the acquisition of carbapenemase genes by these organisms increases the risk of carbapenemase spread in general. Ultimately, infec… Show more

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Cited by 97 publications
(81 citation statements)
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“…Increasing reports of CPNFs, dominated by Pseudomonas aeruginosa and Acinetobacter baumannii, are worrisome as many of these carbapenemase genes have demonstrated mobility across Gram-negative species, regardless of an organism's ability to ferment glucose (3). Lack of recognition and detection of CPNFs may further perpetuate the problem of carbapenem resistance among all Gram-negative organisms.…”
mentioning
confidence: 99%
“…Increasing reports of CPNFs, dominated by Pseudomonas aeruginosa and Acinetobacter baumannii, are worrisome as many of these carbapenemase genes have demonstrated mobility across Gram-negative species, regardless of an organism's ability to ferment glucose (3). Lack of recognition and detection of CPNFs may further perpetuate the problem of carbapenem resistance among all Gram-negative organisms.…”
mentioning
confidence: 99%
“…Additionally, the CDC designated multidrug-resistant (MDR) Pseudomonas aeruginosa and Acinetobacter baumannii as serious threats because they are resistant to nearly all available antibiotics, including carbapenems-declaring that they require urgent public health attention (1). Optimal screening methods for rapid detection of carbapenem-resistant organisms (CROs) have yet to be established (2). Currently described methods include broth enrichment, direct selective culture, chromogenic media, and detection of carbapenemase genes directly from rectal swabs (3)(4)(5)(6)(7)(8)(9).…”
mentioning
confidence: 99%
“…1 However, the hazards posed by CP Pseudomonas aeruginosa and CP Acinetobacter baumannii have been underestimated. 2 The transmission of mobile genetic elements containing carbapenemase-encoding genes is not species specific. Early and accurate detection of CP P. aeruginosa and CP A. baumannii is necessary to prevent the propagation of carbapenemases across all gram-negative organisms in healthcare settings.…”
Section: To the Editormentioning
confidence: 99%