2012
DOI: 10.1016/j.ijantimicag.2011.08.018
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Carbapenem stewardship: does ertapenem affect Pseudomonas susceptibility to other carbapenems? A review of the evidence

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Cited by 60 publications
(40 citation statements)
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“…Previous studies have shown that the use of agents with anti-Pseudomonas activity, such as meropenem and imipenem, is an independent risk factor associated with carbapenem-and multidrug-resistant P. aeruginosa (31,34,35). Meropenem and imipenem are used as empirical therapy for infections due to aerobic Gram-negative bacteria where coverage for P. aeruginosa is not necessary, and the lack of de-escalation of empirical therapy could lead to the elimination of susceptible colonizing microbiota, thus favoring the multiplication of carbapenem-resistant strains (36). Another antibiotic frequently used as empirical therapy in suspected P. aeruginosa infections is piperacillin-tazobactam; this antibiotic has also been associated with the emergence of carbapenem resistance in this pathogen (37,38).…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have shown that the use of agents with anti-Pseudomonas activity, such as meropenem and imipenem, is an independent risk factor associated with carbapenem-and multidrug-resistant P. aeruginosa (31,34,35). Meropenem and imipenem are used as empirical therapy for infections due to aerobic Gram-negative bacteria where coverage for P. aeruginosa is not necessary, and the lack of de-escalation of empirical therapy could lead to the elimination of susceptible colonizing microbiota, thus favoring the multiplication of carbapenem-resistant strains (36). Another antibiotic frequently used as empirical therapy in suspected P. aeruginosa infections is piperacillin-tazobactam; this antibiotic has also been associated with the emergence of carbapenem resistance in this pathogen (37,38).…”
Section: Discussionmentioning
confidence: 99%
“…Among carbapenems, most studies evaluated imipenem or meropenem. There is also some recent experience with ertapenem [Collins et al 2012;Wu et al 2012]; this antibiotic would be preferred for empirical therapy in community-acquired severe infections potentially caused by ESBL producers when coverage against Pseudomonas aeruginosa or Acinetobacter baumannii is not needed to avoid further selection pressure over these organisms [Nicolau et al 2012], since ertapenem lacks significant activity against them. It may also be useful for outpatient parenteral therapy because of the convenience of once daily dosing.…”
Section: Carbapenemsmentioning
confidence: 99%
“…The results of in vitro and clinical studies showed that the use of ertapenem did not decrease susceptibility of P. aeruginosa, Enterobacteriaceae or other gram-negative pathogens to carbapenems [7,12].…”
Section: Discussionmentioning
confidence: 97%
“…The basic strategies of modern approach consist of source control, identification of involved microorganisms, antimicrobial treatment and complex critical care. Postoperative peritonitis is usually classified with a 3 score value on the Carmeli scale and imposes the need for first-line therapy, using a combination of broad-spectrum antibiotics, which usually includes a 2nd generation carbapenem (such as imipenem, meropenem) [7,8]. …”
Section: Introductionmentioning
confidence: 99%