Carbapenemase-producing Gram-negative bacteria in aquatic environments: a review

Cherak, Zineb; Loucif, Lotfi; Moussi, A.; Rolain, Jean‐Marc

doi:10.1016/j.jgar.2021.03.024

Cited by 51 publications

(40 citation statements)

References 191 publications

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“…However, carbapenemases have also been found in many other environments. Carbapenemase-producing bacteria have been found in most aquatic environments including rivers, the sea, well water, sewage, and drinking water [279,280]. Non-aquatic environments also harbour carbapenemases.…”

Section: β-Lactamases Acquired By Horizontal Gene Transfermentioning

confidence: 99%

β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

Glen

Lamont

2021

Pathogens

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Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute and chronic infections. β-lactam antibiotics including penicillins, carbapenems, monobactams, and cephalosporins play a key role in the treatment of P. aeruginosa infections. However, a significant number of isolates of these bacteria are resistant to β-lactams, complicating treatment of infections and leading to worse outcomes for patients. In this review, we summarize studies demonstrating the health and economic impacts associated with β-lactam-resistant P. aeruginosa. We then describe how β-lactams bind to and inhibit P. aeruginosa penicillin-binding proteins that are required for synthesis and remodelling of peptidoglycan. Resistance to β-lactams is multifactorial and can involve changes to a key target protein, penicillin-binding protein 3, that is essential for cell division; reduced uptake or increased efflux of β-lactams; degradation of β-lactam antibiotics by increased expression or altered substrate specificity of an AmpC β-lactamase, or by the acquisition of β-lactamases through horizontal gene transfer; and changes to biofilm formation and metabolism. The current understanding of these mechanisms is discussed. Lastly, important knowledge gaps are identified, and possible strategies for enhancing the effectiveness of β-lactam antibiotics in treating P. aeruginosa infections are considered.

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Section: β-Lactamases Acquired By Horizontal Gene Transfermentioning

confidence: 99%

β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

Glen

Lamont

2021

Pathogens

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“…At first neglected, the environment is now considered as a main player in the emergence and diffusion of AMR. Water plays a major role in interconnecting different ecosystems such as humans, animals, soils and hydrosystems [ 4 , 5 , 6 , 7 , 8 ]. Urban and rural surface waters constitute hotspots for exchanges among microorganisms of human and environmental origin, which are all subject to strong selection pressures due to diverse pollutions [ 3 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…β-lactams are by far the most widely consumed antibiotics worldwide [ 9 ], and among β-lactams, carbapenems are last resort treatment for multidrug-resistant bacterial infections [ 10 , 11 , 12 ]. Several studies reported the occurrence of Carbapenemase Encoding Genes (CEGs) in aquatic environments [ 6 , 7 , 8 ]. However, there is a lack of studies on the persistence and dissemination capacities of CEGs and bacteria carrying CEGs in waters.…”

Section: Introductionmentioning

confidence: 99%

Persistence and Dissemination Capacities of a blaNDM-5-Harboring IncX-3 Plasmid in Escherichia coli Isolated from an Urban River in Montpellier, France

et al. 2022

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To investigate the capacities of persistence and dissemination of blaNDM-5 within Escherichia coli and in aquatic environment, we characterized E. coli (sequence type 636) strains B26 and B28 isolated one month apart from the same urban river in Montpellier, France. The two isolates carried a pTsB26 plasmid, which sized 45,495 Kb, harbored blaNDM-5 gene and belonged to IncX-3 incompatibility group. pTsB26 was conjugative in vitro at high frequency, it was highly stable after 400 generations and it exerted no fitness cost on its host. blaNDM-5harboring plasmids are widely dispersed in E. coli all around the world, with no lineage specialization. The genomic comparison between B26 and B28 stated that the two isolates probably originated from the same clone, suggesting the persistence of pTsB26 in an E. coli host in aquatic environment.

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“…Moreover, as the most signi cant microbial habitat, aquatic environments are known to be favourable for antibiotic gene transfer. It has been reported that they play a crucial role in the spread of drug resistance in the environment (Cherak, Z et al, 2021). As a typical representative of gram-negative bacteria, the adsorption ability of Fe 3 O 4 @Si-OH@CS for E. coli was evaluated.…”

Section: Effect Of Phmentioning

confidence: 99%

Chitosan-silanol groups functional magnetic nanoparticles for heavy metals and bacteria removal

Liu

Yong-hui²,

Liu³

et al. 2022

Preprint

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Studies have shown that there are multiple co-existence pollutants in environmental water over recent years. In this study, we report the design and synthesis of magnetic adsorbents incorporating chitosan-silanol groups (Fe3O4@Si-OH@CS) with improved physicochemical properties for the removal of various heavy metals and bacteria from polluted water. Fe3O4@Si-OH@CS was synthesised using the co-precipitation method. Scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR), Brunauer-Emmett-Teller (BET), Vibrating sample magnetometer (VSM), and Zeta techniques were used to characterise. The effects of factors such as pH, adsorption time, and adsorbent dosage were optimised. The results indicated that Fe3O4@Si-OH@CS had high adsorption efficiency and adsorption capacity for Cr (VI), As, Hg and Se. Moreover, Cr (VI) and As have a preferential adsorption effect when multiple metal ions coexist. The adsorption performance of Fe3O4@Si-OH@CS to bacteria was verified using E. coli (gram-negative) and S. aureus (gram-positive). The developed adsorbent also showed good adsorption efficiency for both gram-negative and gram-positive bacteria. Overall, the synthesised Fe3O4@Si-OH@CS adsorbent showed high removal efficiency and adsorption capacity with a stable structure and easy separation. It has promising applications for the removal of heavy metals and bacteria from water.

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Carbapenemase-producing Gram-negative bacteria in aquatic environments: a review

Cited by 51 publications

References 191 publications

β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

Persistence and Dissemination Capacities of a blaNDM-5-Harboring IncX-3 Plasmid in Escherichia coli Isolated from an Urban River in Montpellier, France

Chitosan-silanol groups functional magnetic nanoparticles for heavy metals and bacteria removal

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