Carbapenems resistance of Acinetobacter spp strains isolated from wound swabs during 2009-2010

Medić, Deana; Mihajlovic-Ukropina, Mira; Gusman, Vera; Jelesić, Zora; Milosavljevic, Biljana

doi:10.2298/mpns1112583m

Cited by 5 publications

(6 citation statements)

References 11 publications

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“…Immunocompromised patients are particularly susceptible. Studies conducted in Bulgaria and Korea confirmed susceptibility of Acinetobacter to colistin, which was also the case in the presented patient 17 . Survival rates in such patients after 1-and 3-year therapy range from 50% and 25%, respectively 9 .…”

Section: Discussionsupporting

confidence: 82%

“…Gram-negative peritonitis is particularly troublesome and severe resulting mostly in technique failure, catheter removal or even lethal out- come 5,6 . The increased incidence of multiresistant strains of Acinetobacter has been reported in Serbia as well as in Italy, Greece, Slovakia, China and USA 16,17 . Multiple myeloma is a disease characterised by a high incidence of severe complications, especially when renal function is disturbed and patients are subjected to any of dialysis methods (HD or PD) 7,8 .…”

Section: Discussionmentioning

confidence: 99%

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An experience with colistin applied in treatment of imunocompromised patients with peritonitis on peritoneal dialysis

Gvozdenović

Majstorović-Strazmester

et al. 2015

VOJNOSANIT PREGL

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Introduction.Immunocompromised patients, such as those with multiple myeloma on peritoneal dialysis, are particularly susceptible to the occurrence of peritonitis. Case report. We presented a 56-year-old female patient with a 10-year history of multiple myeloma. The patient was on peritoneal dialysis since 2010. During 2012 the patient had the first episode of peritonitis that was successfully managed, but in 2013 the second episode of peritonitis occured. Analysis of dialysate culture and exit site swab revealed the presence of multiresistant Acinetobacter spp., which was susceptible only to colistin. Prompt colistin therapy was administered at the doses of 100,000 units/day during six days, which resulted in complete recovery of the patient, as well as improvement of local abdominal findings. Gram-negative bacteria (genus Acinetobacter) are common causative agents in hospital-acquired infections. Studies confirmed susceptibility of Acinetobacter to colistin, which was also the case with the presented patient. Intravenous administration of colistin resulted in a complete remission of this severe, life-threatening peritonitis. Conclusion. Patients with multiple myeloma and renal failure are highly prone to severe life-threatening infections.Uvod. Imunokompromitovani bolesnici, kao što su bolesnici sa multiplim mijelomom na peritoneumskoj dijalizi, posebno su skoloni nastanku peritonitisa. Prikaz bolesnika. Prikazali smo bolesnicu, staru 56 godina, koja je bolovala od multiplog mijeloma 10 godina. Od 2010. god. lečila se metodom peritoneumske dijalize. Prvu epizodu peritonitisa koja je uspešno sanirana, imala je tokom 2012. U 2013. ponovo je došlo do razvoja peritonitisa. Analizom kulture dijalizata i brisom izlaznog mesta peritoneumskog katetera izolovan je multirezistentni Acinetrobacter spp, osetljiv samo na kolistin. Primenom kolistina u dozi od 100 000 jedinica/dan tokom šest dana došlo je do potpunog poboljšanja opšteg stanja bolesnice, kao i lokalnog nalaza na trbuhu. Gramnegativna bakterija (Acinetobacter spp) čest je uzročnik hospitalnih infekcija. Istraživanja potvrđuju osetljivost Acinetobacter spp. na kolistin, što je slučaj kod prikazane bolesnice. Intravenska primena kolistina rezultovala je potpunim oporavkom od teškog, po život opasnog, peritonitisa. Zaključak. Bolesnici sa multiplim mijelomom i bubrežnom insuficijencijom imaju povećanu sklonost ka nastanku teških, po život opasnih, infekcija.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

An experience with colistin applied in treatment of imunocompromised patients with peritonitis on peritoneal dialysis

Gvozdenović

Majstorović-Strazmester

et al. 2015

VOJNOSANIT PREGL

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“…Differences between resistance rates among non‐fermenters from 8% to 34% to beta‐lactam/inhibitor combinations, 19–74% to fluoroquinolones, 17–74% to carbapenems and 3–82% to aminoglycosides were seen worldwide . Reports published in Serbia also show a high prevalence of carbapenem resistance (36–80%) among non‐fermenters …”

Section: Resultsmentioning

confidence: 99%

Correlation between antimicrobial consumption and antimicrobial resistance of Pseudomonas aeruginosa in a hospital setting: a 10-year study

Mladenović-Antić

Kocić

Veličković‐Radovanović

et al. 2016

J Clin Pharm Ther

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“…The resistance of Acinetobacter baumannii to carbapenems, mostly to imipenem, has been the topic of various papers, and the published data on the resistance rates to imipenem have reported from 21% up to 100% of the tested isolates of A. baumannii (15, 16, 17). Among the European countries the resistance rates to carbapenems are highest in the countries in southern Europe, such as Greece and Croatia (14, 19). …”

Section: Discussionmentioning

confidence: 99%

“…Medic et al found that the resistance to cephalosporins third and fourth generations as well as ciprofloxacin was greater than 93% (19). Acinetobacter baumannii isolates are often susceptible only to colistin or tigecycline.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Antibiotic Consumption on Development of Acinetobacter Baumannii Resistance

et al. 2016

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Aim:The aim of this study was to examine the impact of antibiotic consumption on development of antimicrobial resistance in Acinetobacter baumannii.Material and Methods:The study was conducted in University Clinical Center of Sarajevo. In our retrospective study Acinetobacter baumannii isolated in period from July 1st 2009 to December 31st 2012. Isolates were detected from different clinical samples including urine, wound swab, blood, bronchial aspirate and other samples which were collected from patients situated on various hospital wards. Clinical isolates belonged to one per patient in a given period of time.Results:Antimicrobial resistance was interpreted according to CLSI breakpoints. Consumption of antibiotics was analyzed according to recommendations of the ESAC-Net and current Acinetobacter baumannii classification. Pearson’s correlation showed a positive correlation between gentamicin consumption and emerging of resistance (p = 0.023).Conclusion:Increase in the antimicrobial use was followed with an increase in resistance of Acinetobacter baumannii isolates. Monitoring of antibiotic resistance and consumption is of a great importance in order to reduce the emergence and spread of antimicrobial resistant organisms in the health care settings.

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Carbapenems resistance of Acinetobacter spp strains isolated from wound swabs during 2009-2010

Abstract: Our results show high resistance to carbapenems in Acinetobacter spp strains isolated from wound swabs. These facts suggest the need for continuous monitoring of susceptibility in order to take adequate measures to prevent and control spreading of resistant strains.

Cited by 5 publications

References 11 publications

An experience with colistin applied in treatment of imunocompromised patients with peritonitis on peritoneal dialysis

An experience with colistin applied in treatment of imunocompromised patients with peritonitis on peritoneal dialysis

Correlation between antimicrobial consumption and antimicrobial resistance of Pseudomonas aeruginosa in a hospital setting: a 10-year study

The Impact of Antibiotic Consumption on Development of Acinetobacter Baumannii Resistance

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