Carbaryl-14C metabolism in a lactating cow

Dorough, H. W.

doi:10.1021/jf60150a015

Cited by 26 publications

(10 citation statements)

References 8 publications

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“…The specific activity of the kidney and liver was 4 to 10 times greater than the specific activity of the other tissues examined. It is not possible to compare the results directly; nevertheless, it seems likely that the colorimetric assay used in earlier residue studies, which was specific for 1naphthol, did not accurately measure residues which may have been present (Dorough, 1967). It is interesting to note that there was approximately five times as much of the carbon-14 from the carbonyl-labeled compound retained in the tissues than from the ring-labeled compound.…”

Section: Resultsmentioning

confidence: 99%

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The Fate of a Single Oral Dose of Carbaryl (1-Naphthyl N-methylcarbamate) in the Chicken

Paulson¹,

Feil²

1969

Poultry Science

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Section: Resultsmentioning

confidence: 99%

“…Poultry Sci. A more recent study on the metabolism of 14 C-carbaryl in the cow has shown that metabolites of carbaryl are not accu- rately measured by methods which involve hydrolysis followed by colorimetric assay for 1-naphthol (Dorough, 1967). McCully, K. A. W. A.…”

mentioning

confidence: 99%

The Fate of a Single Oral Dose of Carbaryl (1-Naphthyl N-methylcarbamate) in the Chicken

Paulson¹,

Feil²

1969

Poultry Science

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“…The above differences in the chemical nature of Furadancarbonyl-C14 and ring-C14 milk residues directed our attention to the possibility that feeding a carbonyl-C14 labeled carbamate to a cow might result in the radiolabeling of natural milk components. Supporting this possibility was the fact that the extraction characteristics of the carbonyl-C14 Furadan residues in the milk were unlike those of radiolabeled products appearing in the milk of cows treated with either carbaryl-1 -naphthyl-C14 (Borough, 1967) or Temik-S35 (Borough and Ivie, 1968a). Furadan-carbonyl-C14 was readily hydrolyzed in mammalian systems and the resulting carbon-14 dioxide could be collected from the respiratory gases (Borough, 1968).…”

Section: Resultsmentioning

confidence: 99%

Furadan-14C metabolism in a lactating cow

Ivie¹,

Dorough²

1968

J. Agric. Food Chem.

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Furadan (2,3-dihydro-2,2-dimethyl-7-benzofuranyl-A'-methylcarbamate) administered orally to a cow was altered chemically by oxidation of the number 3 carbon and of the VV-methyl group, hydrolysis of the ester linkage, and by conjugation of metabolites containing a hydroxyl group. Carbamate metabolites in the milk were the 3-hydroxy, 3-keto, and 3-hydroxyXV-hydroxymethyl derivatives of Furadan. These materials were present in both the free and conjugated forms. Conjugated 2,3-dihydro-2,2-dimethyl-3-keto-7-hydroxybenzofuran was the major hydrolytic product of Furadan in the milk. The same metabolites also were components of the cow urine and/or feces. Data indicate that of a single oral dose of Furadan fed to a cow, approximately 0.2% would be eliminated in the milk, 0.7% in the feces, and 94% in the urine.

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“…Most carbamates which have been studied are rapidly metabolized by animals, only small residues remaining in the animal. The metabolism of carbaryl (1-naphthyl Nmethylcarbamate) has been studied in rats, guinea pigs, and man (Knaak et al, 1965), in milk goats (Dorough and Casida, 1964), in milk cows (Dorough, 1967), and in dogs (Knaak and Sullivan, 1967). Ten 14C-labeled carbamates were studied in rats by Krishna and Casida (1966).…”

Section: Mobammentioning

confidence: 99%

Metabolism of benzo[b]thien-4-yl methylcarbamate (Mobam) in rats. Balance study and urinary metabolite separation

Robbins¹,

Bakke²,

Feil³

1969

J. Agric. Food Chem.

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The excretion patterns, tissue levels, and ionexchange chromatography of the urinary metabolites of Mobam have been determined in rats. Rats (two groups, 14 per group) were dosed with Mobam-14C (ring-labeled) at 2.0 and 13.0 mg. per kg. of body weight. After 24 hours, 87% (2.0 mg. per kg.) and 76% (13.0 mg. per kg.) of the 14C dose were excreted as water-soluble compounds in the urine. Carcasses of rats from both groups sacrificed at 3 days contained less than 1.0% of the radioactive dose. Tissue residues were fairly evenly distributed, decreasing in the 13.0 mg. per kg. group from an average of 0.5 p.p.m. (wet tissue) after 2 days to 0.2 p.p.m. after 8 days. Anion exchange chromatography on AE cellulose separated the radioactivity in the urine into four fractions. Two metabolites in the urine, 4-benzothienyl sulfate and 4-benzothienyl glucuronide, accounted for 83 and 87% of the excreted 14C from rats dosed at 2.0 and 13.0 mg. per kg., respectively. These metabolites were isolated and purified by liquid ion-exchange chromatography, paper chromatography, gel filtration, and gas-liquid chromatography.

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Carbaryl-14C metabolism in a lactating cow

Cited by 26 publications

References 8 publications

The Fate of a Single Oral Dose of Carbaryl (1-Naphthyl N-methylcarbamate) in the Chicken

The Fate of a Single Oral Dose of Carbaryl (1-Naphthyl N-methylcarbamate) in the Chicken

Furadan-14C metabolism in a lactating cow

Metabolism of benzo[b]thien-4-yl methylcarbamate (Mobam) in rats. Balance study and urinary metabolite separation

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