Carbazole alkaloids from the stems of Clausena excavata

Abstract

A new carbazole alkaloid, sansoakamine (8), together with 11 known compounds, was isolated from the stems of Clausena excavata. All structures were elucidated by spectroscopic methods. Compound 7 showed moderate anti-malarial activity against Plasmodium falciparum with a MIC value of 6.74 microg/ml.

Carbazole Aminoalcohols Induce Antiproliferation and Apoptosis of Human Tumor Cells by Inhibiting Topoisomerase I

“…In general, all test compounds exhibited moderate cytotoxicity,w ith IC 50 values in the micromolar range. The derivatives with aliphatic amino and benzylamino groups (3-7,a nd 15-18)w ere slightly more potent than those possessing aromatic amino groups (8)(9)(10)(11)(12)(13)(14)i n both cell lines. Amongt hem, alkylamine tails (in 5-7)w ere found to be the preferred substituents for cytotoxicity.…”

“…[8][9][10] Carbazole is ap rominentc ore structure found in numerous natural and syntheticc ompounds with awide range of biological activities, including antimalarial, antineoplastic,a nd neuroprotectivee ffects. [11][12][13] In view of anticancer agents, many carbazoled erivatives have been shown to exhibit antitumora ctivity by targeting diverse enzymes or kinases. [14][15][16] However,f ew studies have addressed the relationships between topo Ia nd carbazoles.…”

Synthesis, antimicrobial activity and cytotoxicity of some new carbazole derivatives

“…In the 13 C-NMR spectra of the compounds, the signal of characteristic carbonyl carbon appeared at 166.27 ppm and O-CH 2 at 67.52 ppm, respectively.…”

“…The structure elucidation of the compounds was determined by IR, 1 H-NMR, 13 C-NMR, FAB + -MS spectral data and elemental analyses results.…”

“…These characteristics result in the extensive potential applications of carbazole-based derivatives in the field of chemistry and medicinal chemistry 11 . Carbazole and its derivatives are a considerable structural unit which have been isolated from different sources such as some genera of higher plants, blue green algae, actinomycetes and filamentous fungi [12][13][14] . It is known that natural origin carbazoles especially for those complex carbazoles fusing with a heterocyclic fragment show well-known pharmacological activities 15,16 .…”