Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double‐blind randomised trial

Page, GH

doi:10.1111/j.1471-0528.2010.02739.x

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…In line with the existing literature, the maternal sFlt-1 level in the EO-PE group was significantly higher than LO-PE and control group, while the sFlt-1 levels in the LO-PE group were not different when compared with the control group (Table 2) (19)(20)(21). This finding is in accordance with previous studies, showing the placental involvement/lesion in EO-PE, being minimal or absent in LO-PE.…”

Section: Discussionsupporting

confidence: 92%

Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy

Akbar

Herdiyantini

Aryananda

et al. 2018

Hypertension in Pregnancy

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Objective: To compare the level of serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1), and neonatal outcome in early onset preeclampsia (EO-PE), late onset preeclampsia (LO-PE), and normal pregnancy (NP). Methods: In this prospective observational case control study, HO-1 and sFlt-1 levels were measured in blood samples within 24 h of hospital admission. Preeclampsia cases were divided into two groups based on gestational age at delivery: EO-PE (<34 weeks) and LO-PE (≥34 weeks). A total of 45 patients were involved in this study. Result: Maternal serum level of sFlt-1 was higher in EO-PE than LO-PE and NP groups (mean ± SD; 14.50 ± 17.12 ng/ml vs 5.20 ± 6.69 ng/ml vs 2.72 ± 1.2 ng/ml [p = 0.020]. Maternal serum level of HO-1 was not different between EO-PE, LO-PE, and NP groups (p = 0.681). Birthweights were significantly lower in the EO-PE group compared with the LO-PE and NP groups (1580 ± 536 g vs 2635 ± 578 g vs 3010 ± 371 g [p = 0.000]). The rate of small for gestational age infant (26.7% vs 6.7% vs 0%; p = 0.046) and perinatal death (20% vs 0 vs 0; p = 0.037) was also significantly higher in EO-PE compared to LO-PE and NP. The maternal sFlt-1 level was negatively correlated with birthweight (p = 0.006; CC = −0.445). Conclusion: This study did not find a correlation between maternal HO-1 levels and sFlt-1 levels. Maternal serum sFLt-1 levels in preeclampsia were higher in EO-PE and were associated with a worse perinatal outcome.

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Section: Discussionsupporting

confidence: 92%

Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy

Akbar

Herdiyantini

Aryananda

et al. 2018

Hypertension in Pregnancy

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“…In addition, we tested the effects of the oxytocin analog Butyryl-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Carbetocin, CBT) designed to resist enzymatic cleavage and thus improve the stability of oxytocin in the peripheral circulation. Carbetocin, which is approved for use in many countries outside the United States for the control of postpartum intrauterine hemorrhage (Page, 2010) has been shown to have a longer plasma half-life than oxytocin and longer duration of uterine myometrium contractions (Engstrom et al, 1998). In addition, carbetocin has been shown to modulate certain behaviors when administered peripherally in rats (Chaviaras et al, 2010; Klenerova et al, 2009a, b).…”

Section: Introductionmentioning

confidence: 99%

The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating

Feifel

Shilling

Belcher

2012

European Neuropsychopharmacology

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Converging evidence from preclinical and clinical studies suggest that oxytocin has therapeutic potential for schizophrenia and other neuropsychiatric disorders. Prepulse inhibition of the startle reflex (PPI) is a measure of sensorimotor gating, an important brain function involved in filtering environmental information. We previously demonstrated that systemically administered oxytocin reversed psychostimulant-induced PPI deficits in rats suggesting that oxytocin can produce antipsychotic-like central effects. That finding was supported by a recent trial in humans, which found that intranasal oxytocin reduced symptoms of schizophrenia. The goal of this study was to extend this line of investigation by testing the effects of oxytocin, and a structural analog of oxytocin, carbetocin, on nonpharmacological deficits in PPI. In experiment 1, Brown Norway (BN) rats, a rat strain that has naturally low PPI, were given either saline or one of three doses of oxytocin (0.04 - 1.0 mg/kg, sc). In experiment 2, BN rats were given either saline, one of three doses of carbetocin (0.04 - 1.0 mg/kg) or oxytocin (1 mg/kg). PPI and acoustic startle response (ASR) of rats were tested. Oxytocin significantly increased PPI (P < 0.01) and decreased ASR levels (P < 0.01) in BN rats in a dose-dependent fashion. In contrast, carbetocin had no effect on PPI levels or ASR. The facilitation of BN PPI by oxytocin is similar to what we have previously observed with clozapine and thus further supports oxytocin having antipsychotic properties. In contrast to oxytocin, our data do not support the use of carbetocin as an antipsychotic drug.

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“…Sir, Although the study by Attilakos et al 1 suggests some benefit of carbetocin versus oxytocin, this has to be interpreted with great caution.…”

mentioning

confidence: 99%

Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double‐blind randomised trial

Attilakos

Psaroudakis

Ash

et al. 2010

BJOG

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and seven platelet concentrates were administered. Cyklokapron, Sulprostone, Methergine and Eptacog alpha were also administered. After packing of the uterus with gauzes, the fascia was closed and the patient was transferred to the intensive care unit. At the intensive care unit, haemolysis occurred as a result of the transfusion of uncrossmatched blood and DIC, antibiotics were given and hypotensive periods were treated with noradrenaline. Computed tomography did not show any cerebral, pulmonary or abdominal abnormalities. The patient received hydro-cortisone because amniotic fluid embolism was the most likely diagnosis. Thirty-six hours after PMCS, DIC resolved and the gauzes were removed by relaparotomy. Extubation followed 24 hours later. The symptoms of a paralytic ileus recovered after the administration of erythromycin in combination with a stomach tube and parenteral feeding. Following transfer to the maternity ward an uneventful recovery was seen within a few days. The patient started to remember the day of the induction of labour, became able to perform daily activities and started taking care of her daughter. Two weeks after PMCS, both mother and daughter were discharged without any neurological or other abnormalities. j References 1 Dijkman A, Huisman C, Smit M, Schutte J, Zwart J, van Roosmalen J, et al. Cardiac arrest in pregnancy: increasing use of perimortem caesarean section due to emergency skills training?

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Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double‐blind randomised trial

Cited by 4 publications

References 2 publications

Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy

Serum heme oxygenase 1 (HO-1), soluble FMS like tyrosine kinase (sFlt-1) level, and neonatal outcome in early onset, late onset preeclampsia, and normal pregnancy

The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating

Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double‐blind randomised trial

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