The corrosion behavior of the UNS N10003 alloy in Fenton's reagent was investigated at room temperature for 600 hr by the static immersion method. The results showed that the alloy suffered obvious pitting corrosion. The lattice parameter of this alloy has a slight decrease after corrosion. This is mainly attributed to the depletion of Mo‐rich carbides dissolving into solution caused by the hydroxyl radical with strong oxidization, which is very different from the result of the UNS N10003 alloy under the molten salt condition. The results provide an insight into the corrosion of the alloy under hydroxyl radical conditions (i.e., Fenton's reagent), and will offer a realistic instruction in related fields.