Carbocyclic Amino Ketones by Bredt's Rule‐Arrested Kulinkovich–de Meijere Reaction

Finn, Paul B.; Derstine, Brenden P.; Sieburth, Scott McN.

doi:10.1002/ange.201509983

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Reductive Coupling Reactions1

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2018

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“…A recent modification of the Kulinkovich-de Meijere reaction allows for the synthesis of carbocyclic amino ketones mediated by Ti(O i Pr) 4 /RMgBr (REF 104 ) (FIG. 3b, top).…”

Section: Reductive Coupling Reactionsmentioning

confidence: 99%

Modern applications of low-valent early transition metals in synthesis and catalysis

et al. 2018

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Low-valent early transition metals are often intrinsically highly reactive as a result of their strong propensity toward oxidation to more stable high-valent states. Harnessing these highly reducing complexes for productive reactivity is potentially powerful for C-C bond construction, organic reductions, small-molecule activation and many other reactions that offer orthogonal chemoselectivity and/or regioselectivity patterns to processes promoted by late transition metals. Recent years have seen many exciting new applications of low-valent metals through building new catalytic and/or multicomponent reaction manifolds out of classical reactivity patterns. In this Review, we survey new methods that employ early transition metals and invoke low-valent precursors or intermediates in order to identify common themes and strategies in synthesis and catalysis.

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“…A recent modification of the Kulinkovich-de Meijere reaction allows for the synthesis of carbocyclic amino ketones mediated by Ti(O i Pr) 4 /RMgBr (REF 104 ) (FIG. 3b, top).…”

Section: Reductive Coupling Reactionsmentioning

confidence: 99%