Carbofuran-induced toxicity in rats: Protective role of vitamin C

Kumar, Dinesh; Prashant, K.; Rizvi, Syed Ibrahim; Watal, Geeta; Sharma, Bechan

doi:10.1016/j.etp.2008.11.003

Cited by 62 publications

(59 citation statements)

References 19 publications

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“…The inhibition in GST activity in carbofuran treated rat liver as observed in this study may adversely influence the cascade of Phase II detoxifying reactions in rat liver. The reduction in the level of GST activity has also been reported in rat brain [25] and erythrocytes [26]. In contrast, the acute and chronic doses of carbofuran have been reported to cause elevation in GST activity in rat [10].…”

Section: Discussionmentioning

confidence: 87%

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Hepatoprotective Effect ofCitrus limonFruit Extract against Carbofuran Induced Toxicity in Wistar Rats

Jaiswal

Gupta

Siddiqi

et al. 2015

Chinese Journal of Biology

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Carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranol methylcarbamate), is known to induce oxidative stress and to cause inhibition of acetylcholinesterase activity. The present work was envisaged to evaluate the effect of carbofuran on redox indices and its interactions with hepatic markers in rat. The ameliorating effect of Citrus limon fruit extract on carbofuran induced toxicity was also monitored. The results indicated that carbofuran treatment caused significant alterations in the levels of activities of AST, ALT, and LDH in liver tissues and serum. The levels of enzymatic oxidative stress markers such as SOD and catalase and nonenzymatic redox molecules such as total thiol, GSH, and protein thiol also showed significant perturbations in rat liver due to carbofuran treatment. The administration of Citrus limon fruit extract, however, was able to markedly ameliorate the toxicity of carbofuran by protecting the levels of aforesaid biomarkers to near normal levels. The ameliorative effect of Citrus limon fruit extract may be due to the presence of different antioxidants in it which may neutralize the ROS and RNS generated in the body tissue due to pesticide stress. These results suggested that Citrus limon fruit extract may be utilized as a potential supplement in proper management of pesticide intoxication in association with relevant therapeutics.

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Section: Discussionmentioning

confidence: 87%

“…The pesticide induced free radicals mediated toxicity, however, may be ameliorated by introduction of extracts from some traditional Indian medicinal plants [17,[24][25][26]. The aim of the present study was to evaluate the hepatoprotective effect of C. limon fruit extract against carbofuran induced toxicity in rats.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect ofCitrus limonFruit Extract against Carbofuran Induced Toxicity in Wistar Rats

Jaiswal

Gupta

Siddiqi

et al. 2015

Chinese Journal of Biology

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“…Osmotic fragility of erythrocytes demonstrates the integrity of red cell membranes in pathological and normal states (Rai et al, 2009). The present results obtained from osmotic fragility tests of sickle cell blood showed increased fragility compared to normal red blood cells.…”

Section: Discussionmentioning

confidence: 99%

“…Acute toxicity studies in rodents also reveal LD 50 of Allium sativum to be 3g/Kg body weight (Singh and Singh, 2008) Sickle cell anemia is an inherited blood disease, in which, when red cells are deoxygenated, produce a fibrous polymer which stiffen erythrocyte membrane and alters ionic transport. In addition it has generally been observed that human erythrocytes are perhaps the cells most exposed to peroxidative damage by free radicals due to the high cellular concentration of oxygen and hemoglobin; a potentially powerful promoter of oxidative processes (Rother et al, 2005; Jaiswal and Rizvi, 2011) However other studies shown that the red blood cell protects itself against oxidative damage by antioxidants located in both cytosolic and membrane domains which counter the effect of antioxidant and also free radicals (Rai et al, 2009). Since previous studies (Steiner and Varga, 2003) showed the presence of both antioxidant and hemolytic agents in garlic, it will be expedient to know if normal and sickle erythrocytes have the same pattern of fragility when treated with garlic and graded concentrations of NaCl.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Aqueous Extract of Allium Sativum (Garlic) on Erythrocyte Osmotic Fragility in Normal and Sickle Cell

Adegoke¹,

Adamu²,

Ige³

et al. 2014

AJLS

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Allium sativa (garlic) is a bulbous herb used as food item, spice and medicine in different parts of the world. The effect of garlic (Allium Sativa) on the osmotic fragility of red blood cells in normal and sickle cell patients was assessed in vitro. The study comprised four sets of fourteen centrifuge tubes each containing 5ml of graduated concentrations of normal saline. To the first set of tubes, 20µl of blood from normal subjects was added using a micropipette, while to the second, 0.75mg of garlic and 20µl of blood from normal subjects were added. To the third set of tubes, 20µl of blood from sickle cell patient was added, and to the fourth 20µl of blood from sickle cell patient and 0.75mg of garlic were added. Percentage hemolysis was determined by spectrophotometry. It was observed that the degree of hemolysis was greater (P<0.05) in the sickle cell compared to the normal blood. This observation was also recorded in the samples treated with garlic. It is concluded that the degree of hemolysis in sickle cell is higher (P<0.05) than normal cell. Treatment with garlic increased fragility in both normal and sickle cell blood however this effect was more pronounced in sickle cell blood. It is recommended that the consumption of garlic in patients with sickle cell anemia should be continuously monitored and carefully regulated.

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“…These insecticides are broad spectrum neurotoxic with a wide host range from insects to mammals. Many researchers have found that this toxicity acts over insects and also non-target groups of organisms (Jiang and Ma, 2000;Rai et al, 2009). The insect pest on cotton crop in India became tolerant to organophosphate insecticides, which triggered the process of re-thinking about the use of chemicals for pest control.…”

Section: Management Tactics Of Helicoverpamentioning

confidence: 99%

Microbial agents against Helicoverpa armigera: Where are we and where do we need to go?

Vijayabharathi¹,

Kumari²,

Gopalakrishnan³

2014

Afr. J. Biotechnol.

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Plants are prone to various biotic stresses in nature by bacteria, viruses, fungi, parasites, harmful insects and weeds. The biggest percentage loss (70%) in plants is attributed to insects. Lepidoptera is one such diversified phytophagous insect group, which include Helicoverpa armigera, a key pest of many food crops including chickpea, pigeonpea, pea, lentil, chillies, sunflower, tomato, tobacco and cotton. Controlling this insect has been a big task for farmers leading to the manufacture of a plethora of pesticides. However, over reliance on chemical pesticides has resulted in problems including safety risks, environmental contamination, outbreaks of secondary pests, insecticide resistance and decrease in biodiversity. Hence, there is an urgent need for the development of eco-friendly methods such as entomopathogens, antagonist or competitor populations of a third organism and botanicals to suppress H. armigera. Also, many compounds from microorganisms have been found to be effective in crop production, and these have a role in controlling H. armigera. The actinomycetes play an astounding role in controlling the key plant pathogens. They are the representative genera of higher microbial mass in the soil. Numerous studies have shown that these productive actino-bacteria can generate an impressive array of secondary metabolites such as antibiotics, antitumor agents, insecticides etc. This review emphasizes the mechanism behind resistance to insecticides along with actinomycetes and its potential as a biocontrol agent against H. armigera.

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Carbofuran-induced toxicity in rats: Protective role of vitamin C

Cited by 62 publications

References 19 publications

Hepatoprotective Effect ofCitrus limonFruit Extract against Carbofuran Induced Toxicity in Wistar Rats

Hepatoprotective Effect ofCitrus limonFruit Extract against Carbofuran Induced Toxicity in Wistar Rats

The Effect of Aqueous Extract of Allium Sativum (Garlic) on Erythrocyte Osmotic Fragility in Normal and Sickle Cell

Microbial agents against Helicoverpa armigera: Where are we and where do we need to go?

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