Carbohydrate-actuated nanofluidic diode: switchable current rectification in a nanopipette

Vilozny, Boaz; Wollenberg, Alexander L.; Actis, Paolo; Hwang, Daniel; Singaram, Bakthan; Pourmand, Nader

doi:10.1039/c3nr02105j

Cited by 46 publications

(44 citation statements)

References 62 publications

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“…If the charge is switched from positive to negative, the system changes from anion to cation‐selective, and consequently, the rectification of the ionic current becomes reverted as well. This modulation of the current rectification is of high importance for technological applications, especially for biosensing …”

Section: Resultsmentioning

confidence: 99%

Phosphate‐Responsive Biomimetic Nanofluidic Diodes Regulated by Polyamine–Phosphate Interactions: Insights into Their Functional Behavior from Theory and Experiment

Pérez-Mitta

Marmisollé

Albesa

et al. 2017

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There is currently high interest in developing nanofluidic devices whose iontronic output is defined by biological interactions. The fabrication of a phosphate responsive nanofluidic diode by using the biological relevant amine-phosphate interactions is shown. The fabrication procedure includes the modification of a track-etched asymmetric (conical) nanochannel with polyallylamine (PAH) by electrostatic self-assembly. PAH is the arcaetypical model of polyamine and it is further used to address the nanochannels with phosphate responsivity. In order to explore the influence that phosphate in solution has in the conductance of the modified nanochannels, current-voltage measurements using different concentrations of phosphates are performed. Furthermore, to have a complete physicochemical understanding of the system, experimental data is analyzed using a continuous model based on Poison-Nernst-Planck equations and compared with results obtained from stochastic Monte Carlo simulations.

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Section: Resultsmentioning

confidence: 99%

Phosphate‐Responsive Biomimetic Nanofluidic Diodes Regulated by Polyamine–Phosphate Interactions: Insights into Their Functional Behavior from Theory and Experiment

Pérez-Mitta

Marmisollé

Albesa

et al. 2017

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“…Furthermore, due to the tendency of the boronates to form complexes with diols modifying the acidic constants of the native form, it is possible to modulate the pH responsiveness with the concentration of sugar in solution, e.g., fructose. We should note that sugar sensing in nanofluidic devices has been investigated in the past; however, rather than focusing on the sensing capabilities of PAPBA‐modified nanopores, the purpose of this work is to explore new avenues to gain “chemical” control over the ionic transport properties of nanofluidic elements by using chemical effectors to set different pH‐controlled transport regimes.…”

Section: Introductionmentioning

confidence: 99%

Proton‐Gated Rectification Regimes in Nanofluidic Diodes Switched by Chemical Effectors

Pérez-Mitta

Marmisollé

Burr

et al. 2018

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During the last decade, nanofluidic devices based on solid-state nanopores and nanochannels have come into scene in materials science and will not leave anytime soon. One of the main reasons for this is the excellent control over ionic transport exerted by such devices that promises further important advances when integrated into more complex molecular devices. As a result, pH, temperature, and voltage-regulated devices have been obtained. However, nowadays, there is still a necessity for molecule-driven nanofluidic devices. Here, a sugar-regulated pH-responsive nanofluidic diode is presented obtained by surface modification of conical polycarbonate nanochannels with electropolymerized 3-aminophenylboronic acid. Control over the ionic transport has been achieved by a successful decoration of asymmetric nanochannels with integrated molecular systems. The as-synthesized boronate-appended zwitterionic polymer exhibits an acid-base equilibrium that depends on the concentration of sugar, which ultimately acts as a chemical effector setting different pH-dependent rectification regimes. As a result, the same nanodevice can perform completely different proton-regulated nanofluidic operations, i.e., anion-driven rectification, cation-driven rectification, and no rectification, by simply varying the concentration of fructose in the electrolyte solution.

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“…13,14 Nanoporous polymer 15– 17 and solid-state 18–20 membranes have been fabricated to display diode-like behavior. 21,22 Combinations of these diodic elements comprise the basic units of nanofluidic electronics such as logic-gates 23,24 or externally coupled circuitry 25 potentially useful in lab-on-a-chip technologies.…”

Section: Introductionmentioning

confidence: 99%

Modulation of Molecular Flux Using a Graphene Nanopore Capacitor

Shankla

Aksimentiev²

2017

J. Phys. Chem. B

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Modulation of ionic current flowing through nanoscale pores is one of the fundamental biological processes. Inspired by nature, nanopores in synthetic solid-state membranes are being developed to enable rapid analysis of biological macromolecules and to serve as elements of nanofludic circuits. Here, we theoretically investigate ion and water transport through a graphene-insulator-graphene membrane containing a single, electrolyte-filled nanopore. By means of all-atom molecular dynamics simulations we show that the charge state of such a graphene nanopore capacitor can regulate both the selectivity and the magnitude of the nanopore ionic current. At a fixed transmembrane bias, the ionic current can be switched from being carried by an equal mixture of cations and anions to being carried almost exclusively by either cationic or anionic species, depending on the the sign of the charge assigned to both plates of the capacitor. Assigning the plates of the capacitor opposite sign charges can either increase the nanopore current or reduce it substantially, depending on the polarity of the bias driving the transmembrane current. Facilitated by dynamic inversion of the nanopore surface charge, such ionic current modulations are found to occur despite the physical dimensions of the nanopore being an order of magnitude larger than the screening length of the electrolyte. The ionic current rectification is accompanied by a pronounced electro-osmotic effect that can transport neutral molecules such as proteins and drugs across the solid-state membrane and thereby serve as an interface between electronic and chemical signals.

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Carbohydrate-actuated nanofluidic diode: switchable current rectification in a nanopipette

Cited by 46 publications

References 62 publications

Phosphate‐Responsive Biomimetic Nanofluidic Diodes Regulated by Polyamine–Phosphate Interactions: Insights into Their Functional Behavior from Theory and Experiment

Phosphate‐Responsive Biomimetic Nanofluidic Diodes Regulated by Polyamine–Phosphate Interactions: Insights into Their Functional Behavior from Theory and Experiment

Proton‐Gated Rectification Regimes in Nanofluidic Diodes Switched by Chemical Effectors

Modulation of Molecular Flux Using a Graphene Nanopore Capacitor

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