2021
DOI: 10.15420/cfr.2021.22
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Carbohydrate Antigen 125: A Biomarker at the Crossroads of Congestion and Inflammation in Heart Failure

Abstract: Because heart failure (HF) is more lethal than some of the common malignancies in the general population, such as prostate cancer in men and breast cancer in women, there is a need for a cost-effective prognostic biomarker in HF beyond natriuretic peptides, especially concerning congestion, the most common reason for the hospitalisation of patients with worsening of HF. Furthermore, despite diuretics being the mainstay of treatment for volume overload in HF patients, no randomised trials have shown the mortali… Show more

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Cited by 11 publications
(15 citation statements)
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“…Another parameter currently used to determine the degree of congestion in heart failure is the CA-125 level. In this study, CA-125 levels were significantly associated with less IVC collapsibility and were, therefore, more predictive of the degree of congestion [ 13 , 14 , 15 , 16 ]. This association between decreased inferior vena cava collapsibility values and elevated CA-125 values suggests that these parameters are more elevated in those subjects with a higher degree of pulmonary hypertension and right HF.…”
Section: Discussionmentioning
confidence: 92%
“…Another parameter currently used to determine the degree of congestion in heart failure is the CA-125 level. In this study, CA-125 levels were significantly associated with less IVC collapsibility and were, therefore, more predictive of the degree of congestion [ 13 , 14 , 15 , 16 ]. This association between decreased inferior vena cava collapsibility values and elevated CA-125 values suggests that these parameters are more elevated in those subjects with a higher degree of pulmonary hypertension and right HF.…”
Section: Discussionmentioning
confidence: 92%
“…CA-125-guided diuretic therapy was associated with a significant reduction in death and readmission for AHF at 30 days. The CA-125-guided group exhibited a considerably greater improvement in renal function (increase in GFR) in comparison to the standard treatment group [ 133 ]. Given the long half-life (over a week) of CA-125, it does not provide any information about acute response to therapy [ 132 ].…”
Section: Congestionsmentioning
confidence: 99%
“…CA-125 is associated with congestion, right-sided HF parameters, and an increased risk of adverse clinical events in AHF, beyond standard prognostic factors such as natriuretic peptides [ 133 ]. Broad availability, standardized measurement, and low cost make it a compelling candidate for routine use in decompensated HF.…”
Section: Congestionsmentioning
confidence: 99%
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