Carbohydrate antigen 125 levels and clinical outcomes after off-pump coronary artery bypass grafting

Li, Jing; Song, Shu-Jiang; Liu, Fulin; Lou, Zhi-Qiang; Han, Zhiwei; Wang, Yan; Zhou, Xiaodong; Cheng, Zhiyuan; Liu, Ke-Ye

doi:10.1097/mca.0000000000000262

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…29 In a research on DR, obvious phosphorylation of c-Jun N-terminal kinase (JNK) signaling pathway was observed in microglial cells of retina, leading to polarization to M1 cell and triggering excessive inflammation Coincidently, CA125 synthesis is achieved through JNK signaling pathway of mesothelial cells. 30 However, whether inflammation in retina associates with CA125 expression through the JNK pathway still needs further exploration. Potential signal pathway for the association between CA125 and DR was shown in Figure 2.…”

Section: Discussionmentioning

confidence: 99%

<p>Serum CA125 Level Is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes</p>

Yao¹,

Zhong²,

He³

et al. 2020

DMSO

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Background: To investigate the association between serum carbohydrate antigen 125 (CA125) and the presence as well as severity of diabetes retinopathy (DR) in Chinese adult patients with type 2 diabetes. Methods: A hospital-based cross-sectional study was conducted from February 2012 to November 2018. DR was assessed using Early Treatment Diabetic Retinopathy Study criteria. Vision-threatening DR (VTDR) was diagnosed if subjects had severe nonproliferative DR (NPDR), proliferative DR (PDR), or clinically significant macular edema (CSME). Multivariate logistic regression models were applied to explore the associations. Results: Among the 2696 participants, the overall prevalence of DR was 25.1%, of which the prevalence of mild NPDR, moderate NPDR, and VTDR was 10.8%, 4.5%, and 9.9%, respectively. Serum CA125 level was significantly higher in participants with DR and increased with the severity of DR (P = 0.013). After accounting for age, gender, smoking, drinking, duration of diabetes, anti-diabetic agents use, systolic blood pressure, pulse pressure, weight, hemoglobin A1c and fasting plasma glucose levels, CA125 level was significantly associated with subjects in any-severity DR

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Section: Discussionmentioning

confidence: 99%

<p>Serum CA125 Level Is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes</p>

Yao¹,

Zhong²,

He³

et al. 2020

DMSO

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Prognostic value of carbohydrate antigen 125 in patients undergoing surgical left ventricular reconstruction

Nan

Tiemuerniyazi²,

Chen³

et al. 2023

International Journal of Cardiology

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Chronic Medical Conditions and CA125 Levels among Women without Ovarian Cancer

Akinwunmi

Babić

Vitonis

et al. 2018

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Randomized trials using the biomarker CA125, with or without pelvic ultrasound, have failed to show a clear benefit of general population screening for ovarian cancer. In part this may be due to a lack of information about conditions, besides ovarian cancer, that can alter CA125 levels and affect specificity or sensitivity. We evaluated the association between common medical conditions and CA125 levels among women without ovarian cancer. Methods: We used data and specimens from 2,004 women without ovarian cancer who participated in the New England Case Control study between 1992 and 2008. Participants completed in-person interviews and donated blood samples at enrollment. We measured CA125 using the CA125II assay and calculated the association between medical conditions and log-transformed CA125 using linear regression. Results: The median age of participants was 53 years and 1,119 (56%) were postmenopausal. The average CA125 level was 14.5 units/mL for premenopausal and 11.7 for postmenopausal women. Among premenopausal women, CA125 was significantly lower for women with colon polyps (p=0.06) and hysterectomy (p=0.01) and significantly higher with endometriosis (p=0.05). CA125 was also significantly higher in premenopausal women with coronary artery disease (CVD) (p<0.01, n=2 cases) but not among postmenopausal with CVD (n=79). Further, among postmenopausal women, CA125 was significantly lower for women with osteoporosis, hypercholesterolemia, and osteoarthritis (p=0.03, 0.02 and 0.01 respectively) and higher for women with a history of inflammatory bowel disease (p=0.04). Conclusion: Several chronic diseases are associated with CA125, which could influence the interpretation of CA125 in the context of ovarian cancer screening.

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Carbohydrate antigen 125 levels and clinical outcomes after off-pump coronary artery bypass grafting

Abstract: An increased preoperative CA125 level is an independent predictor of worse clinical outcomes after OPCAB during a 1-year follow-up.

Cited by 5 publications

References 16 publications

<p>Serum CA125 Level Is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes</p>

<p>Serum CA125 Level Is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes</p>

Prognostic value of carbohydrate antigen 125 in patients undergoing surgical left ventricular reconstruction

Chronic Medical Conditions and CA125 Levels among Women without Ovarian Cancer

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