Carbohydrate Biopolymers Enhance Antibody Responses to Mucosally Delivered Vaccine Antigens

Bacon, Andrew; Makin, J.; Sizer, Philip J.H.; Jabbal‐Gill, Inderjit; Hinchcliffe, Michael; Illum, Lisbeth; Chatfield, Steven N.; Roberts, Mark

doi:10.1128/iai.68.10.5764-5770.2000

Cited by 134 publications

(62 citation statements)

References 57 publications

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“…Chitosan has shown promising results in i.n. split virus vaccines in mice (Bacon et al 2000), split virus and protein vaccines in humans (Read et al 2005;Sui, Chen, Fang, et al 2010;Sui, Chen, Wu, et al 2010) and split virus and DNA vaccines in poultry (Tischer et al 2002;Worrall et al 2009;Huang et al 2010;Rauw et al 2010). However, in our study vaccination with chitosan-adjuvanted inactivated AIV and TMC inactivated AIV particles did not induce AIV-specific serum Ig (de Geus et al 2011).…”

Section: 2contrasting

confidence: 51%

Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines

Geus

Rebel

Vervelde

2012

Veterinary Quarterly

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The risk and the size of an outbreak of avian influenza virus (AIV) could be restricted by vaccination of poultry. A vaccine used for rapid intervention during an AIV outbreak should be safe, highly effective after a single administration and suitable for mass application. In the case of AIV, aerosol vaccination using live virus is not desirable because of its zoonotic potential and because of the risk for virus reassortment. The rational design of novel mucosal-inactivated vaccines against AIV requires a comprehensive knowledge of the structure and function of the lung-associated immune system in birds in order to target vaccines appropriately and to design efficient mucosal adjuvants. This review addresses our current understanding of the induction of respiratory immune responses in the chicken. Furthermore, possible mucosal vaccination strategies for AIV are highlighted.

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Section: 2contrasting

confidence: 51%

Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines

Geus

Rebel

Vervelde

2012

Veterinary Quarterly

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“…Chitosan has shown promising results in i.n. split virus vaccines in mice (Bacon et al, 2000), split virus and protein vaccines in human (Read et al, 2005;Sui et al, 2010a,b) and a split virus vaccine in poultry (Worrall et al, 2009;Rauw et al, 2010). It was previously shown that CT is an effective mucosal adjuvant in chicken (Vervelde et al, 1998), but CT cannot be used in the field because of its toxicity.…”

Section: Introductionmentioning

confidence: 99%

A lack of antibody formation against inactivated influenza virus after aerosol vaccination in presence or absence of adjuvantia

Geus

Haarlem

Poetri

et al. 2011

Veterinary Immunology and Immunopathology

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a b s t r a c tIn the poultry industry, infections with avian influenza virus (AIV) can result in significant economic losses. The risk and the size of an outbreak might be restricted by vaccination of poultry. A vaccine that would be used for rapid intervention during an outbreak should be safe to use, highly effective after a single administration and be suitable for mass application. A vaccine that could be applied by spray or aerosol would be suitable for mass application, but respiratory applied inactivated influenza is poorly immunogenic and needs to be adjuvanted. We chose aluminum OH, chitosan, cholera toxin B subunit (CT-B), and Stimune as adjuvant for an aerosolized vaccine with inactivated H9N2. Each adjuvant was tested in two doses. None of the adjuvanted vaccines induced AIV-specific antibodies after single vaccination, measured 1 and 3 weeks after vaccination by aerosol, in contrast to the intramuscularly applied vaccine. The aerosolized vaccine did enter the chickens' respiratory tract as CT-B-specific serum antibodies were detected after 1 week in chickens vaccinated with the CT-B-adjuvanted vaccine. Chickens showed no adverse effects after the aerosol vaccination based on weight gain and clinical signs. The failure to detect AIV-specific antibodies might be due to the concentration of the inactivated virus.

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“…Hayvan hücrelerinde yapılan çalışmalarda da kitosanın hayvanların bağışıklık sistemlerini uyararak veya virüsün bağlanma reseptörleri ile hayvan hücresinin viral reseptörleri arasında gerçekleşen etkileşimi önleyerek antiviral etki sergilediği ifade edilmektedir [56,57]. …”

Section: Antiviral Mekanizmaunclassified

Ki̇tosan Ve Anti̇mi̇krobi̇yal Özelli̇kleri̇

Yıldırım

Öncül²,

Yildirim

2016

Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi

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ÖZKitosan, kitinin kısmen veya tamamen deastilasyonuyla elde edilen değişik moleküler ağrılıktaki bileşikler için kullanılan genel bir terimdir. Doğada yaygın ve bol miktarda bulunması, yüksek canlılara karşı toksik etki göstermemesi, mikroorganizmaları inhibe etmesi, biyolojik olarak parçalanabilmesi, biyo-uyumlu olması, kimyasal ve fiziksel özellikleri bakımından diğer birçok biyopolimere göre üstün özellikler göstermesi nedeniyle kitosan başta gıda olmak üzere su, ilaç, kozmetik, ziraat, tıp, kâğıt, tekstil, mikrobiyoloji, immünoloji, biyoteknoloji, ters osmoz membranları gibi birçok alanda kullanım olanağı bulmaktadır. Bu derleme, kitosanın antimikrobiyal aktivitesi ve etki mekanizması, antimikrobiyal aktivitesini etkileyen faktörler ve gıda endüstrisinde kullanımı ile ilgili bilgileri içermektedir.Anahtar Kelimeler: Kitosan, antimikrobiyal aktivite, etki mekanizması, gıda CHITOSAN AND ANTIMICROBIAL PROPERTIES ABSTRACTChitosan is a collective name used for a group of compounds having various molecular weights, which are produced from chitin by partially or fully de-acetylating. Because of its distinctive biological and physicochemical properties, including non-toxic, biocompatible, biodegradable, antimicrobial, antioxidant, anticancer and non-antigenic activities, chitosan has found many applications in different areas such as: food, water treatment, pharmaceutical, cosmetics, agriculture, biomedical, paper, textile, microbiology, immunology, biotechnology and reverse osmosis membranes. This review gives information about antimicrobial activity of chitosan, its mode of action against microorganisms, factors affecting its antimicrobial activity and its application in food industry.Keywords: Chitosan, antimicrobial activity, mode of action, food GİRİŞKitosan [(C 6 H 11 NO 4 ) n (C 8 H 13 NO 4 ) m ], ilk kez Bradconnot tarafından 1811 yılında tanımlanmış olan kitinin (β-1,4-poli-N-asetil-D-glukozamin) kısmen veya tamamen deasetilasyonu ile elde edilen antimikrobiyal özelliğe sahip bir heteropolisakkarittir [1,2]. Kitinin deasetilasyonu sonucu elde edildiği için kitosan, farklı oran ve sayıda 2-amino-2-deoksi-β-D-glukopiranoz (D-glukozamin, deasetile form, yaklaşık % 80) ve 2-asetamido-2-deoksi-β-D-glukopiranoz (N-asetil-D-glukozamin, asetile form, yaklaşık % 20) moleküllerinin β-(1,4) bağı ile bağlanması sonucu oluşan düz zincirli bir kopolimerdir. Bu iki molekülün sayısı ve dizi içerisindeki sırası

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Carbohydrate Biopolymers Enhance Antibody Responses to Mucosally Delivered Vaccine Antigens

Cited by 134 publications

References 57 publications

Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines

Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines

A lack of antibody formation against inactivated influenza virus after aerosol vaccination in presence or absence of adjuvantia

Ki̇tosan Ve Anti̇mi̇krobi̇yal Özelli̇kleri̇

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