Carbohydrate-Containing Materials in Urine from Normal and Diabetic Subjects

Abstract

1. Abnormalities in glycoprotein metabolism are believed to play a role in diabetic microangiopathy. We have therefore measured the urinary excretion of carbohydrate-containing materials in normal and diabetic subjects. 2. Diabetic subjects were found to excrete excessive quantities of such material, which may parallel the increases observed in plasma and structural glycoproteins found in previous studies. 3. Systemic administration of a synthetic derivative of vasicine, which is known to affect mucus glycoprotein, was shown to restore these elevated urinary concentrations seen in diabetic subjects to values close to normal, but his drug had no significant effect on urinary concentrations of such materials in normal subjects.

Effects of Imidazole-2-Hydroxibenzoate on Glycosaminoglycan and Albumin Urinary Excretion in Type 1 Diabetic Patients

“…The results of this study indicate that ITF-182, a com pound which is both a NSA1D and an imidazole deriva tive, brings about a reduction in the rate of urinary GAG excretion in 1DD patients in whom an abnormally high urinary excretion of GAGs and other correlated mole cules has been found [3][4][5][6], The meaning of these urinary biochemical abnormalities is still under debate, mainly in view of the contradictory reports on the effects of human and experimental diabetes on systemic proteoglycan me tabolism. In fact, it has been reported both a decreased concentration and biosynthesis of sulfated GAGs, an increase of their degradation, and some molecular changes in proteoglycans.…”

“…Diabetes mellitus is characterized among others by both qualitative and quantitative modifications of base ment membrane glycosaminoglycans (G AGs) [ 1,2] which are also mirrored in an altered urinary excretion of G AGs [3][4][5] and other correlated molecules [6], This GAG de rangement seems closely related to some complications of diabetes, namely atherosclerosis and diabetic neph ropathy, for which the most widely accepted viewpoint suggests that the disturbance in glomerular basement membrane GAG metabolism is related to the onset of 'microalbuminuria' [7] which appears to be a good pre dictor of the later development of clinical nephropathy [8], In this setting, any action aimed at correcting GAG metabolism should be able to slow down the onset of diabetic nephropathy.…”

Urinary Glycosaminoglycans, Sialic Acid and Lysosomal Enzymes Increase in Nonalbuminuric Diabetic Patients

“…Urinary GAGS and SA excretion are increased in diabetes [21,22], but both are normal constitutents of the extracellular matrix and basement membranes, and con sequently they are found all along the nephron and uri nary tract; it follows that they do not necessarily reflect glomerular involvement. We cannot demonstrate a link between increased urinary excretion of GAGS and SA and glomerular challenge, but we have attempted an indirect answer to this question by evaluating the same parameters in mesangial glomerulonephritic patients without interstitial involvement; in fact, their urine chemistry pattern was very similar to that of IDD pa tients, thus strengthening the thesis that the biochemical urinary anomalies mirror a glomerular involvement in non-'microalbuminuric' IDD patients.…”

Review & Future Perspectives of Using Vasicine, and Related Compounds

“…(1979) [44] that, it can restore the balance in glucose level in the urine of diabetic patients but, has no effect on normal patient. They suggested that, this change may be due to reduction in the amount of glycoprotein and related material in the body, or from a change in the catabolism of these materials.…”