Carbohydrate Deficient Transferrin in a Driver's License Regranting Program

Abstract

Applying a marker for chronic alcohol abuse such as CDT for driver's license renewal or regranting is a powerful tool. Analysis of data collected over 2.5 years reveals a favorable outcome of the program and a useful cut-off point could be determined.

Immunonephelometric Carbohydrate-Deficient Transferrin Results and Transferrin Variants

“…There is limited evidence for the effect of mutant Tf on CDT test results, mainly because of the small number of participants who were enrolled in the evaluation study (2 ). Because Tf variants are common findings (particularly in non-Caucasian populations) (3,4 ), knowledge of the performance of immunonephelometric tests in the presence of Tf mutants is of practical importance. In the present study, we compared the effect of Tf variants on CZE and nephelometric CDT testing.…”

Improved recovery of repeat intoxicated drivers using fingernails and blood spots to monitor alcohol and other substance abuse

“…European countries since the 1980s to help road authorities make informed and objective decisions while re-granting drivers' licenses (Gjerde et al, 1986;Bjerre et al, 2007, Bortolotti et al, 2007Maenhout et al, 2012). This growing field called Traffic Medicine sometimes uses alcohol biomarkers as tools to monitor the drinking behavior of intoxicated drivers and to ascertain drivers' risk.…”

“…For instance in Italy, after an OWI arrest, the driver's license is confiscated, and the driver must undergo a medical examination which includes testing with alcohol biomarkers in order to regain their driving privileges (Bortolotti et al, 2007). In Belgium, judges have the authority to order the OWI offender to participate in a driver's license re-granting program, and biomarkers are used to monitor adherence to the abstinence program (Maenhout et al, 2012;Maenhout et al, 2014). Sweden also uses a medical review program that ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 4 links the reductions of biomarker values to the successful completion of interlock programs (Bjerre et al, 2007).…”

“…The majority of previous biomarker approaches reported with OWI offenders have used indirect biomarkers, mostly Carbohydrate Deficient Transferrin (CDT) and gamma glutamyltransferase (GGT) in Europe and CDT and the Early Detection of Alcohol Consumption (EDAC) test in the U.S. (Gjerde et al, 1986;Korzec et al, 2001;Bortolotti et al, 2007;Bean et al, 2009;Maenhout et al, 2012;Bean et al, 2013;Maenhout et al, 2014). Only a handful of studies (Marques et al, 2010;Marques et al, 2011, Marques et al, 2014 have used direct biomarkers to detect alcohol use in intoxicated drivers in Canada with encouraging results.…”

Determination of carbohydrate-deficient transferrin in a Han Chinese population

“…Currently, CDT is recognized as an independent alcohol marker, with reliable sensitivity and specificity to identify heavy drinking [9]. For over 4.5 years, it has been used in traffic medicine among subjects applying for driver’s license renewal or regranting in Belgium [10]. In addition to effectively estimating alcohol consumption, CDT also provides a novel tool to diagnose alcohol-related diseases.…”