Carbohydrate-DNA Conjugation Enabled by Glycosyl Radicals Generated from Glycosyl Sulfinates

Abstract

Herein, we report a method that enables the synthesis of carbohydrate-DNA conjugates by radical addition, in which the gen-eration of glycosyl radicals from readily available and bench-stable unprotected glycosyl sulfinates is the key. These reactions were carried out under mild conditions and tolerate a broad substrate scope.