2003
DOI: 10.1046/j.1440-1754.2003.00159.x
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Carbohydrate intolerance and kidney stones in children in the Goldfields

Abstract: Renal stones have been reported as a common finding in Australian Aboriginal children. The stones are predominantly urate in composition. We report on five children with nephrolithiasis from the Goldfields region of Western Australia. All were diagnosed when under 5 years of age, the majority being under 3 years. All five children also had lactose intolerance, and we postulate that carbohydrate malabsorption, together with the ensuing chronic diarrhoea and intraluminal breakdown of sugars by enteric bacteria m… Show more

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Cited by 16 publications
(14 citation statements)
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“…Finally, Baldwin et al . from Kalgoorlie presented five cases of renal stones, postulating that the development of renal stones was due to a chronic metabolic acidosis from lactose intolerance . Although lactose intolerance was documented, chronic metabolic acidosis was not, and some of the young children also had gastroenteritis with dehydration or urine infections.…”
Section: Renal Stonesmentioning
confidence: 99%
“…Finally, Baldwin et al . from Kalgoorlie presented five cases of renal stones, postulating that the development of renal stones was due to a chronic metabolic acidosis from lactose intolerance . Although lactose intolerance was documented, chronic metabolic acidosis was not, and some of the young children also had gastroenteritis with dehydration or urine infections.…”
Section: Renal Stonesmentioning
confidence: 99%
“…Chronic metabolic acidosis can result in protein metabolism and thus increased excretion of urate and formation of kidney stones 10. Pure uric acid stones are rare but recur frequently.…”
Section: Risk Factors For Kidney Stonesmentioning
confidence: 99%
“…Experimental data available are limited. A study conducted on Australian Aborigine children implies that lactose intolerance is linked with kidney stone formation (mainly urate calculi) in determining chronic metabolic acidosis that, in turn, leads to protein catabolism, increased urate excretion and thus formation of calculi [8]. A noteworthy 12-year study by Choi and coworkers on the relationship between dietary risk factors and new cases of gout [9], investigated the above-mentioned relationship in a population of 47,150 men who did not present gout when recruited in the study.…”
Section: Discussionmentioning
confidence: 99%