Carbohydrate Metabolism in Rats With Acute Uremia

Abstract

To define areas of carbohydrate metabolism which might be altered in uremia, determinations of gastric and intestinal absorption of glucose and deposition of glycogen in the liver of 9 acutely uremic and 24 control rats were performed. Residual gastric and intestinal glucose contents and hepatic glycogen contents were determined 3 hours after glucose lavage in rats fasted for 24 hours. No statistically significant difference was observed in gastrointestinal absorption of glucose and in hepatic deposition of glycogen of the uremic and control animals.

Uremia and the Liver. III. Uremia and Hepatic Metabolism of Carbohydrates, Lipids and Proteins

“…No changes in glycogen synthesis or degradation have been reported in a number of studies carried out on liver slices from normal rats incubated with uremic serum [5] or in livers from uremic animals [8,[14][15][16]. However.…”