Carbohydrate Metabolism

Somogyi, M

doi:10.1146/annurev.bi.11.070142.001245

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…If these clusters encode genes involved either in the alternative PLP synthesis route or in the catabolism of an unknown sugar, an obvious missing component is a kinase. A common step in sugar catabolism is phosphorylation, and as discussed above, the 4HT route to PLP requires a kinase. The three-dimensional structure of two members of the DUF1537 family, both from the YgbK subgroup (PDB IDs: 3DQQ and 1YZY), had been solved through the structural genomics effort at the time of our analysis.…”

Section: Resultsmentioning

confidence: 99%

Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite

et al. 2016

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DUF1537 is a novel family of kinases identified by comparative genomic approaches. The family is widespread and found in all sequenced plant genomes and 16% of sequenced bacterial genomes. DUF1537 is not a monofunctional family and contains subgroups that can be separated by phylogenetic and genome neighborhood context analyses. A subset of the DUF1537 proteins is strongly associated by physical clustering and gene fusion with the PdxA2 family, demonstrated here to be a functional paralog of the 4-phosphohydroxy-l-threonine dehydrogenase enzyme (PdxA), a central enzyme in the synthesis of pyridoxal-5'-phosphate (PLP) in proteobacteria. Some members of this DUF1537 subgroup phosphorylate l-4-hydroxythreonine (4HT) into 4-phosphohydroxy-l-threonine (4PHT), the substrate of PdxA, in vitro and in vivo. This provides an alternative route to PLP from the toxic antimetabolite 4HT that can be directly generated from the toxic intermediate glycolaldehyde. Although the kinetic and physical clustering data indicate that these functions in PLP synthesis are not the main roles of the DUF1537-PdxA2 enzymes, genetic and physiological data suggest these side activities function has been maintained in diverse sets of organisms.

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Section: Resultsmentioning

confidence: 99%

Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite

et al. 2016

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“…Zur Methodik: Die Methode SOMOGYI(22) (siehe auch POMMERENKE[20] und VIER-G T E~E R und POMMERENKIS [241) erwies sich vor allen Dingen fur die Bestimmung von reduzierenden Substanzen in aunerordentlich g e r i n g e n hl e n y e n von Untersuchungsmaterial mit cinem Gehalt bis etwa 0,8 mg red. Substanz von Vorteil.…”

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Untersuchungen über reduzierende Substanzen in männlichen Geschlechtssekreten von Rind und Hund

Kaemmerer

Neumann²

2010

Zeitschrift Für Tierzüchtung Und Züchtungsbiologie

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The origin and differentiation of the alpha and beta cells in the pancreatic islets of the rat

Hard

1944

Am. J. Anat.

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Carbohydrate Metabolism

Cited by 7 publications

References 21 publications

Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite

Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite

Untersuchungen über reduzierende Substanzen in männlichen Geschlechtssekreten von Rind und Hund

The origin and differentiation of the alpha and beta cells in the pancreatic islets of the rat

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