2019
DOI: 10.1021/acsapm.9b00141
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Carbohydrate Sensing Using Water-Soluble Poly(methacrylic acid)-co-3-(Acrylamido)phenylboronic Acid Copolymer

Abstract: Carbohydrate and saccharide sensing in water remains very challenging. Using the covalent reversible interaction between boronic acids and the diol groups in carbohydrates is still one of the most common approaches. However, the binding affinity and solubility of isolated boronic acids are poor in water, which significantly limits their application in physiological conditions. In this work, we improved the solubility and affinity of this interaction by connecting phenylboronic acid moieties to a hydrophilic po… Show more

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Cited by 21 publications
(16 citation statements)
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“…Another recent example of sugar-sensing by Bonizzoni and colleagues is a polymer-dye complex involving a copolymer of poly(methacrylic acid) and 3-(acrylamido)phenylboronic acid (PMAA-co-AAPBA). 116 Both a hematoxylin and cyanidin chloride dye illustrated suitable binding to the boronic acid functionality on the polymer and were examined as sensing units in an IDA approach. The dyes and their polymer-dye complexes were exposed to eight common sugars, and spectra were collected across multiple absorbance and emission wavelength channels.…”
Section: Polymers Decorated With Chromophores and Fluorophoresmentioning
confidence: 99%
“…Another recent example of sugar-sensing by Bonizzoni and colleagues is a polymer-dye complex involving a copolymer of poly(methacrylic acid) and 3-(acrylamido)phenylboronic acid (PMAA-co-AAPBA). 116 Both a hematoxylin and cyanidin chloride dye illustrated suitable binding to the boronic acid functionality on the polymer and were examined as sensing units in an IDA approach. The dyes and their polymer-dye complexes were exposed to eight common sugars, and spectra were collected across multiple absorbance and emission wavelength channels.…”
Section: Polymers Decorated With Chromophores and Fluorophoresmentioning
confidence: 99%
“…Biomaterials can be engineered to respond specifically to the microenvironment of the site of injury or disease, 148 as is often done with the acidic environment of cancer cells. 114,149 pH sensitive vehicles are typically made through the integration of polyelectrolytes, such as phenylboronic acid (PBA), [150][151][152] due to their ability to change their overall charge at different pH, resulting in triggered release. 114,153,154 Cong et al crosslinked chitosan with glycerol 2-phospate disodium to created pH sensitive micelles, which were then dispersed in an alginate hydrogel.…”
Section: Environmentally-responsive Materialsmentioning
confidence: 99%
“…LDA finds the linear combinations of the raw instrumental measurements that minimize the size of the cluster of replicates pertaining to each sample (intracluster distances) while maximizing the distances among clusters belonging to different analytes (intercluster distances), thus providing optimal separation among analyte clusters [29,30]. This method has been used for the discrimination of various analytes, including bacteria [31], proteins [32], wines [33], sugars [34,35], metal ions [36,37], food additives [38], and drugs [39].…”
Section: Antibiotics Discrimination At Ph 74mentioning
confidence: 99%