1978
DOI: 10.1073/pnas.75.5.2315
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Carbohydrate structure and cell differentitation: unique properties of fucosyl-glycopeptides isolated from embryonal carcinoma cells.

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Cited by 150 publications
(63 citation statements)
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“…With this in mind, a micro-immunoassay procedure was designed recently (Tang et al, 1985;Tang & Feizi, 1987) (Muramatsu et al, 1978;Childs et al, 1983;Pennington et al, 1985). To the left are shown unsubstituted poly-N-acetyl-lactosamine backbones, with short branches reactive with anti-I Ma (Feizi et al, 1971) and M18 (Gooi et al, 1983c) antibodies (Ma+, M 18+); long branched sequences reactive with anti-I Step (Step+) and unbranched sequences reactive with anti-i Den (Den+).…”
Section: Glycoprotein Oligosaccharides As Major Antigens Of Whole Cellsmentioning
confidence: 99%
“…With this in mind, a micro-immunoassay procedure was designed recently (Tang et al, 1985;Tang & Feizi, 1987) (Muramatsu et al, 1978;Childs et al, 1983;Pennington et al, 1985). To the left are shown unsubstituted poly-N-acetyl-lactosamine backbones, with short branches reactive with anti-I Ma (Feizi et al, 1971) and M18 (Gooi et al, 1983c) antibodies (Ma+, M 18+); long branched sequences reactive with anti-I Step (Step+) and unbranched sequences reactive with anti-i Den (Den+).…”
Section: Glycoprotein Oligosaccharides As Major Antigens Of Whole Cellsmentioning
confidence: 99%
“…20,21) Furthermore, B16 melanoma cells that expressed sialyl Lewis X on long poly N acetyllactosamine were highly metastatic, while cells expressing even more sialyl Lewis X on short poly N acetyllactosamine were not metastatic.…”
Section: )mentioning
confidence: 99%
“…19) The amounts of poly N acetyllactosamine chains have been shown to be changed during cellular differentiation and malignant transformation of cells. 20,21) Furthermore, B16 melanoma cells that expressed sialyl Lewis X on long poly N acetyllactosamine were highly metastatic, while cells expressing even more sialyl Lewis X on short poly N acetyllactosamine were not metastatic. 22) In addition, poly N acetyllactosamines have been shown to be directly recognized with high affinity by galectins, 23) and to be involved in apoptosis.…”
mentioning
confidence: 99%
“…have recently described large differentiation sensitive fucosyl glycopeptides in mouse teratoma stem cells, which may well be stricturally unique among mammalian glycoprotein glycans (9).…”
Section: Introductionmentioning
confidence: 99%