Carbohydrate Supplementation Before Operation Retains Intestinal Barrier Function and Lowers Bacterial Translocation in a Rat Model of Major Abdominal Surgery

Abstract

Preoperative intake of carbohydrates by rats retains both the intestinal barrier function and prevents translocation of bacteria to distant organs.

Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences

“…Treatment of the gut with the mucolytic Nacetylcholine resulted in a failure of mucus restitution upon I/R and further increased gut permeability and injury, underlining that the mucus layer not only serves as a barrier between the luminal contents and gut surface epithelia but also plays a critical role in the maintenance and restitution of gut barrier function [126]. In line with this, preoperative intake of carbohydrates by rats is reported to retain both the intestinal barrier function and to prevent translocation of bacteria to distant organs [127]. Fasting per se has been shown to promote mucosal apoptosis via a receptor-mediated type I apoptotic pathway in the rat small intestine [128].…”

Novel nutritional substrates in surgery

“…CHO loading preserves the energy status of the liver and most importantly reduces insulin resistance ( 107 ) . Also, it improves intestinal integrity and reduces bacterial translocation ( 108 ) .…”

Carbohydrate supplementation retains intestinal barrier and ameliorates bacterial translocation in an antibiotic-induced mouse model

“…5 For example, preoperative intake of carbohydrates results in a better-maintained intestinal barrier function; this improvement in intestine might lead to the prevention of BT and consequent systemic infection. [6][7][8] Konjac glucomannan (KGM), which is extracted from the roots and tubers of Amorphophallus konjac, is a typical high polymer dietary fiber with health benefits including suppressing obesity, reducing cholesterol and promoting intestinal activity. KGM consists of β-1,4-linked D-mannosyl and D-glucosyl in a molar ratio of 1.6 : 1.0, with certain branching points at the C-3 position of both D-glucosyl and D-mannosyl residues, 9 and some at the C-6 positions of glucosyl units.…”

“…5 For example, preoperative intake of carbohydrates results in a better-maintained intestinal barrier function; this improvement in intestine might lead to the prevention of BT and consequent systemic infection. 6–8…”