Carbon‐11, Nitrogen‐13, and Oxygen‐15 Chemistry

Copper(II)-Mediated [11C]Cyanation of Arylboronic Acids and Arylstannanes

“…2 A number of methods have been developed for [ 11 C]-radiolabeling, and some of the most attractive involve the late-stage introduction of a [ 11 C]CN substituent (Scheme 1). 3 [ 11 C]Cyanide offers an advantage because it can be readily generated from [ 11 C]CO 2 . 1,2 Additionally, the nitrile functionality is common in bioactive molecules 4 and can also be rapidly transformed into other important functional groups, including amides, carboxylic acids, and amines (Scheme 1).…”