Carbon-14 distribution and elimination in chickens given carbon-14-labeled methoprene

Davison, K. L.

doi:10.1021/jf60205a002

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…The remainder is a great variety of metabolites in the yolk and white including most of those also detected in the excreta. Residues of permethrin-derived products in yolk reach peak levels 3 or 4 days after those in white in a similar manner to the metabolites of other xenobiotics (Andrawes et al, 1972;Davison, 1976;Paulson and Zehr, 1971). Radiocarbon from dermally applied 14C-methylene-labeled (lfí)-c¿s,írans-permethrin reaches maximum yolk levels at the fifth day after treatment (Hunt et al, 1978) in agreement with the present findings on oral administration of the individual trans and cis isomers.…”

Section: Discussionmentioning

confidence: 96%

Distribution and metabolic fate of trans- and cis-permethrin in laying hens

Gaughan¹,

Robinson²,

Casida³

1978

J. Agric. Food Chem.

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Radiocarbon from 14C-carbonyl-and 14C-methylene-labeled preparations of (1 RS)-trans-and (1PS)ci's-permethrin, administered to laying hens for 3 consecutive days at 10 mg/kg for each dose, is largely eliminated from the body within 1 day after the last dose, a portion as 14C02. The excreta contain all and the eggs most of the following compounds identified by thin-layer cochromatography with authentic standards and specific enzymatic hydrolysis: the unmetabolized pyrethroids; cis-permethrin hydroxylated at the 4'-position, at the methyl group trans to the carboxyl, and at both of these sites; the dichlorovinyl acids and their derivatives hydroxylated at the trans or cis methyl group; phenoxybenzyl alcohol,

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Section: Discussionmentioning

confidence: 96%

Distribution and metabolic fate of trans- and cis-permethrin in laying hens

Gaughan¹,

Robinson²,

Casida³

1978

J. Agric. Food Chem.

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“…According to Oberlander et al (2000), methoprene significantly inhibits cell proliferation after exposure in lepidopteron imaginal cell line. Published studies showed that methoprene was absorbed, metabolized mainly through ester hydrolysis and excreted following oral dose in rats (Hawkins et al, 1977, Wright, 1976, in chickens (Davison, 1976;Quistad et al, 1976), and in guinea pigs and cows (Chamberlain et al, 1975).…”

Section: Introductionmentioning

confidence: 99%

A solid phase extraction reversed‐phase HPLC method for the simultaneous determination of methoprene, permethrin and selected metabolites in rat plasma and urine

Abu-Qare¹,

Abou‐Donia²

2001

Biomedical Chromatography

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A method was validated and applied for the analysis of the insect growth regulator methoprene [Isopropyl (2E,4E)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate], its metabolite methoprene acid, the insecticide permethrin [3-(2,2-dichloro-ethenyl)-2,2-dimethylcyclopropanecarboxylic acid(3-phenoxyphenyl)methylester], and two of its metabolites, m-phenoxybenzyl alcohol and m-phenoxybenzoic acid, in rat plasma and urine using solid-phase extraction and reversed-phase high performance liquid chromatography. The analytes were separated using gradient of 55-100% acetonitrile in water (pH 4.0) at a flow rate ranging between 0.6 and 1.0 mL/min over a period of 20 min, and UV detection at 210 and 254 nm. The retention times ranged from 7.3 to 18.4 min. The limits of detection ranged between 50 and 100 ng/ml, while limits of quantitation were 100-150 ng/mL. Average percentage recovery of five spiked plasma samples was 83.6 +/- 3.9, 80.1 +/- 5.4, 82.1 +/- 4.4, 83.7 +/- 3.9 and 83.1 +/- 4.7, and from urine 79.3 +/- 4.3, 82.0 +/- 5.4, 80.7 +/- 4.2, 78.9 +/- 5.7 and 83.9 +/- 4.5 for methoprene, methoprene acid, permethrin, m-phenoxybenzyl alcohol and m-phenoxybenzoic acid, respectively. The method was linear and reproducible over the range of 100-1000 ng/mL. This method was applied to analyze the above chemicals and metabolites following their combined administration in rats.

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Biological and environmental dynamics of insect growth regulators (IGRs) as used against Diptera of public health importance

Mian

Mulla

1982

Residue Reviews

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Carbon-14 distribution and elimination in chickens given carbon-14-labeled methoprene

Cited by 5 publications

References 9 publications

Distribution and metabolic fate of trans- and cis-permethrin in laying hens

Distribution and metabolic fate of trans- and cis-permethrin in laying hens

A solid phase extraction reversed‐phase HPLC method for the simultaneous determination of methoprene, permethrin and selected metabolites in rat plasma and urine

Biological and environmental dynamics of insect growth regulators (IGRs) as used against Diptera of public health importance

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