Carbon-Based Nanomaterials: Multifunctional Materials for Biomedical Engineering

Cha, Chaenyung; Shin, Su Ryon; Annabi, Nasim; Dokmeci, Mehmet R.; Khademhosseini, Ali

doi:10.1021/nn401196a

Cited by 751 publications

(454 citation statements)

References 51 publications

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“…Moreover, carbon nanotubes and graphene show enhanced laser absorption in the near-infrared (NIR) region and high photothermal-conversion efficiency and can act as photothermal agents for photothermal cancer therapy. Pre-clinical evaluations of biodistribution, excretion, histocompatibility, hemocompatibility, and other properties are very encouraging: sp 2 carbon-based biomaterials are nontoxic and biocompatible at adequate doses, showing high clinical-translation potential [20,22,23].…”

Section: Introductionmentioning

confidence: 99%

Mesoporous carbon biomaterials

Chen

Shi

2015

Sci. China Mater.

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Nano-biotechnology provides highly efficient and versatile strategies to improve the diagnostic precision and therapeutic efficiency of serious diseases. The development of new biomaterial systems provides great opportunities for the successful clinical translation of nano-biotechnology for personalized biomedicine to benefit patients. As a new inorganic material system, mesoporous carbon biomaterials (

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Section: Introductionmentioning

confidence: 99%

Mesoporous carbon biomaterials

Chen

Shi

2015

Sci. China Mater.

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“…Conducting polymers, although very useful, suffer from instability in some environments, some pH dependent conductivity, and challenges in material processing and device fabrication [18,19] . The application of carbon nanotubes has been restricted due to toxicity issues, arising from cellular uptake and induced oxidative stress to cells [20][21][22] as well as agglomeration during processing. On the other hand, graphene based materials have had a profound impact in the biomedical field thanks to their excellent electrical conductivity, high mechanical strength, ease of functionalization with biomolecules, ability to induce electrical conductivity to biopolymers and facile processing [22][23][24][25][26][27] .…”

Section: Introductionmentioning

confidence: 99%

“…The application of carbon nanotubes has been restricted due to toxicity issues, arising from cellular uptake and induced oxidative stress to cells [20][21][22] as well as agglomeration during processing. On the other hand, graphene based materials have had a profound impact in the biomedical field thanks to their excellent electrical conductivity, high mechanical strength, ease of functionalization with biomolecules, ability to induce electrical conductivity to biopolymers and facile processing [22][23][24][25][26][27] . Graphene has also been shown to increase cell proliferation [28] and is able to be excreted from the body through the renal system, phagocytosis and endocytosis indicating its suitability for implantation [29][30][31][32] .…”

Section: Introductionmentioning

confidence: 99%

High‐Performance Multifunctional Graphene‐PLGA Fibers: Toward Biomimetic and Conducting 3D Scaffolds

Esrafilzadeh

Jalili

Stewart

et al. 2016

Adv Funct Materials

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The development of electrically conducting fibers based on known cytocompatible materials is of interest to those engaged in tissue regeneration using electrical stimulation. Herein, it is demonstrated that with the aid of rheological insights, optimized formulations of graphene containing spinnable poly(lactic-co-glycolic acid) (PLGA) dopes can be made possible. This helps extend the general understanding of the mechanics involved in order to deliberately translate the intrinsic superior electrical and mechanical properties of solutionprocessed graphene into the design process and practical fiber architectural engineering. The as-produced fibers are found to exhibit excellent electrical conductivity and electrochemical performance, good mechanical properties, and cellular affinity. At the highest loading of graphene (24.3 wt%), the conductivity of as-prepared fibers is as high as 150 S m-1 (more than two orders of magnitude higher than the highest conductivity achieved for any type of nanocarbon-PLGA composite fibers) reported previously. Moreover, the Young's modulus and tensile strength of the base fiber are enhanced 647-and 59-folds, respectively, through addition of graphene. Disciplines Engineering | Physical Sciences and Mathematics Publication DetailsEsrafilzadeh, D., Jalili, R., Stewart, E. M., Aboutalebi, S. H., Razal, J. M., Moulton, S. The development of electrically conducting fibers based on known cytocompatible materials is of interest to those engaged in tissue regeneration using electrical stimulation. Herein, we demonstrate that with the aid of rheological insights, optimized formulations of graphene 2 containing spinnable Poly Lactic-co-Glycolic Acid (PLGA) dopes can be made possible. This helps us extend our general understanding of the mechanics involved in order to deliberately translate the intrinsic superior electrical and mechanical properties of solution-processed graphene into the design process and practical fiber architectural engineering. The asproduced fibers were found to exhibit excellent electrical conductivity, and electrochemical performance, good mechanical properties, and cellular affinity. At the highest loading of graphene (24.3 wt. %), the conductivity of as-prepared fibers was as high as 150 S m −1 (more than 2 orders of magnitude higher than the highest conductivity achieved for any type of nanocarbon-PLGA composite fibers) reported previously. Moreover, the Young's modulus and tensile strength of the base fiber were enhanced 647-and 59-folds, respectively, through addition of graphene.

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“…For example, ZnO and TiO 2 NPs are widely utilized in cosmetic, coating, paint, and electronic industries (Dange et al, 2007;Franklin et al, 2007;Hall et al, 2009). Ag NPs are employed in a variety of consumer products due to their antimicrobial activity (Dobrzynska et al, 2014), and carbon nanotubes (CNTs) have a range of applications, such as biomedicine (Cha et al, 2013), sewage treatment (Kar et al, 2012), electronics, and sensors (Bennett et al, 2013). Consequently, environmental concentrations of NPs, though being modeled and/or measured to be in levels of mg/L or much less, were estimated to increase exponentially (Gottschalk et al, 2009(Gottschalk et al, , 2013.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical transformation and algal toxicity of engineered nanoparticles in surface water samples

Zhang

Yang

et al. 2016

Environmental Pollution

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a b s t r a c tMost studies on the behavior and toxicity of engineered nanoparticles (NPs) have been conducted in artificial water with well-controlled conditions, which are dramatically different from natural waters with complex compositions. To better understand the fate and toxicity of NPs in the natural water environment, physicochemical transformations of four NPs (TiO 2 , ZnO, Ag, and carbon nanotubes (CNTs)) and their toxicities towards a unicellular green alga (Chlorella pyrenoidosa) in four fresh water and one seawater sample were investigated. Results indicated that water chemistry had profound effects on aggregation, dissolution, and algal toxicity of the NPs. The strongest homoaggregation of the NPs was associated with the highest ionic strength, but no obvious correlation was observed between the homoaggregation of NPs and pH or dissolved organic matter content of the water samples. The greatest dissolution of ZnO NPs also occurred in seawater with the highest ionic strength, while the dissolution of Ag NPs varied differently from ZnO NPs. The released Zn 2þ and especially Ag þ mainly accounted for the algal toxicity of ZnO and Ag NPs, respectively. The NP-cell heteroagglomeration occurred generally for CNTs and Ag NPs, which contributed to the observed nanotoxicity. However, there was no significant correlation between the observed nanotoxicity and the type of NP or the water chemistry. It was thus concluded that the physicochemical transformations and algal toxicities of NPs in the natural water samples were caused by the combined effects of complex water quality parameters rather than any single influencing factor alone. These results will increase our knowledge on the fate and effects of NPs in the aquatic environment.

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Carbon-Based Nanomaterials: Multifunctional Materials for Biomedical Engineering

Cited by 751 publications

References 51 publications

Mesoporous carbon biomaterials

Mesoporous carbon biomaterials

High‐Performance Multifunctional Graphene‐PLGA Fibers: Toward Biomimetic and Conducting 3D Scaffolds

Physicochemical transformation and algal toxicity of engineered nanoparticles in surface water samples

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