Carbon-Based Solid Acid as an Efficient and Reusable Catalyst for the Synthesis of 1,8-Dioxodecahydroacridines Under Solvent-Free Conditions

Abstract

Carbon-based solid acid catalyst was found to be highly efficient, eco-friendly and recyclable heterogeneous catalyst for the multicomponent reaction of dimedone, aromatic aldehydes, and a nitrogen source (ammonium acetate or aromatic amines) under solvent-free conditions, giving rise to 1,8-dioxodecahydroacridines in high yields. The present methodology offers several advantages, such as a simple procedure with an easy work-up, short reaction times, high yields, and the absence of any volatile and hazardous organic solvents.

Extraordinary catalytic activity of a Keplerate-type giant nanoporous isopolyoxomolybdate in the synthesis of 1,8-dioxo-octahydroxanthenes and 1,8-dioxodecahydroacridines

“…As part of our research on the development of environmentally friendly methods for synthesis of organic compounds using reusable catalysts [53][54][55] Fig. 1), as a highly efficient and reusable novel catalyst to promote the following organic transformations under solvent-free conditions: (1) the synthesis of 1,8-dioxo-octahydroxanthenes 5a-j from dimedone 1 (2 eq.)…”

A Highly Efficient and Fast Method for the Synthesis of Biscoumarins Using Tetrabutylammonium Hexatungstate [TBA]2[W6O19] as Green and Reusable Heterogeneous Catalyst

“…Prompted by these findings and interest on the development of novel synthetic methodologies in organic reactions, [24][25][26][27] in this paper for the first time a highly efficient and fast method for the synthesis of biscoumarins by reaction of 4-hydroxycoumarin with aromatic aldehydes using tetrabutyl- for 3 h to obtain a white cream. Then a solution of acetic anhydride (20 mL) and HCl (12 N, 18 mL) in DMF (50 mL) is added with stirring, and the resulting mixture is filtered off to eliminate the undissolved white solid.…”

Study on one-pot four-component synthesis of 9-aryl-hexahydro-acridine-1,8-diones using SiO2–I as a new heterogeneous catalyst and their anticancer activity

“…1 MCRs contribute to the requirements of an environment friendly process by reducing the number of synthetic steps, energy consumption and waste production. 2 Therefore, developing new MCRs and improvement of known MCRs are popular areas of research in the current synthetic organic chemistry.…”