Carbon-Based Sorbent Coatings for the Determination of Pharmaceutical Compounds by Bar Adsorptive Microextraction

Ahmad, Samir M.; Mestre, Ana S.; Neng, Nuno R.; Ania, Conchi O.; Carvalho, Ana P.; Nogueira, J.M.F.

doi:10.1021/acsabm.9b01206

Cited by 6 publications

(3 citation statements)

References 46 publications

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“…The four commercial ACs used included the CA1 (pH PZC : 2.2; surface area ( A BET ): 1043 m 2 g −1 ; V mesopores : 0.66 cm 3 g −1 ; V α supermicropores : 0.26 cm 3 g −1 ), the CN1 (pH PZC : 5.1; surface area ( A BET ): 1179 m 2 g −1 ; V mesopores : 0.68 cm 3 g −1 ; V α supermicropores : 0.30 cm 3 g −1 ) and the SX PLUS (pH PZC : 8.4; surface area ( A BET ): 833 m 2 g −1 ; V mesopores : 0.44 cm 3 g −1 ; V α supermicropores : 0.15 cm 3 g −1 ; V α ultramicropores : 0.08 cm 3 g −1 ) from Salmon & Cia (Portugal) and the R (pH PZC : 6.5; surface area ( A BET ): 964 m 2 g −1 ; V mesopores : 0.40 cm 3 g −1 ; V α supermicropores : 0.16 cm 3 g −1 ; V α ultramicropores : 0.09 cm 3 g −1 ) from Riëdel-de Haën (Hannover, Germany). The textural and surface properties of the commercial ACs were assessed according to the procedures described by Ahmad et al [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

HS-BAμE: A New Alternative Approach for VOCs Analysis—Application for Monitoring Biogenic Emissions from Tree Species

et al. 2023

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In this work, a new analytical approach is proposed for monitoring biogenic volatile organic compounds (BVOCs) by combining headspace bar adsorptive microextraction (HS-BAμE) with gas chromatography–mass spectrometry (GC-MS). The HS-BAμE methodology was developed, optimized, validated and applied for the analysis of BVOCs emitted from two tree species (Eucalyptus globulus Labill. and Pinus pinaster Aiton) and compared with headspace solid phase microextraction (HS-SPME), commonly accepted as a reference technique. To achieve optimum experimental conditions, numerous assays were carried out by both methodologies, studying the release of the five major monoterpenoids (α-pinene, β-pinene, myrcene, limonene and 1,8-cineole) from the leaves of the tree species, whereas the maximum selectivity and efficiency were obtained using an activated carbon and PDMS/DVB fiber as sorbent phases for HS-BAμE and HS-SPME, respectively. Under optimized experimental conditions, both methodologies showed similar profiling and proportional responses, although the latter present a higher sensitivity in the analytical configuration used. For the five monoterpenoids studied, acceptable detection limits (LODs = 5.0 μg L−1) and suitable linear dynamic ranges (20.0–100.0 mg L−1; r2 ≥ 0.9959) were achieved, and intra- and inter-day studies proved that both methodologies exhibited good results (RSD and %RE ≤ 19.9%), which indicates a good fit for the assessment of BVOCs by the HS-BAμE/GC-MS methodology. Assays performed on sampled leaves by both optimized and validated methodologies showed high levels of the five major BVOCs released from E. globulus Labill. (10.2 ± 1.3 to 7828.0 ± 40.0 μg g−1) and P. pinaster Aiton (9.2 ± 1.4 to 3503.8 ± 396.3 μg g−1), which might act as potential fuel during forest fire’s propagation, particularly under extreme atmospheric conditions. This is the first time that BAμE technology was applied in the HS sampling mode, and, in addition to other advantages, it has proven to be an effective and promising analytical alternative for monitoring VOCs, given its great simplicity, easy handling and low cost.

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Section: Methodsmentioning

confidence: 99%

HS-BAμE: A New Alternative Approach for VOCs Analysis—Application for Monitoring Biogenic Emissions from Tree Species

et al. 2023

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“…Apart from other microextraction approaches such as solid-phase microextraction (SPME) or stir bar sorptive extraction (SBSE) [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ], bar adsorptive microextraction (BAμE), which was introduced in the last decade, presents several advantages and has shown great simplicity and versatility by allowing the choice of sorbent coating for each particular type of application. Materials such as activated carbons (ACs) prepared from several sources, alumina, silica, cork, polystyrene divinylbenzene (PS-DVB), modified pyrrolidine, silica-based polymers, and nanomaterials, such as carbon nanotubes, and multi-walled carbon nanotubes have been used, demonstrating great performance as sorbent phases for BAμE technique [ 14 , 15 , 16 , 17 , 18 , 19 ]. Nevertheless, the preparation and application of new materials with specific sorption characteristics is still very important for particular applications, especially those from ecological sources, such as biomaterial waste.…”

Section: Introductionmentioning

confidence: 99%

Application of Bar Adsorptive Microextraction for the Determination of Levels of Tricyclic Antidepressants in Urine Samples

et al. 2021

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This work entailed the development, optimization, validation, and application of a novel analytical approach, using the bar adsorptive microextraction technique (BAμE), for the determination of the six most common tricyclic antidepressants (TCAs; amitriptyline, mianserin, trimipramine, imipramine, mirtazapine and dosulepin) in urine matrices. To achieve this goal, we employed, for the first time, new generation microextraction devices coated with convenient sorbent phases, polymers and novel activated carbons prepared from biomaterial waste, in combination with large-volume-injection gas chromatography-mass spectrometry operating in selected-ion monitoring mode (LVI-GC-MS(SIM)). Preliminary assays on sorbent coatings, showed that the polymeric phases present a much more effective performance, as the tested biosorbents exhibited low efficiency for application in microextraction techniques. By using BAμE coated with C18 polymer, under optimized experimental conditions, the detection limits achieved for the six TCAs ranged from 0.2 to 1.6 μg L−1 and, weighted linear regressions resulted in remarkable linearity (r2 > 0.9960) between 10.0 and 1000.0 μg L−1. The developed analytical methodology (BAμE(C18)/LVI-GC-MS(SIM)) provided suitable matrix effects (90.2–112.9%, RSD ≤ 13.9%), high recovery yields (92.3–111.5%, RSD ≤ 12.3%) and a remarkable overall process efficiency (ranging from 84.9% to 124.3%, RSD ≤ 13.9%). The developed and validated methodology was successfully applied for screening the six TCAs in real urine matrices. The proposed analytical methodology proved to be an eco-user-friendly approach to monitor trace levels of TCAs in complex urine matrices and an outstanding analytical alternative in comparison with other microextraction-based techniques.

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“…In the last decade, bar adsorptive microextraction (BAμE) has been reported as an alternative enrichment technique that uses activated carbons (ACs) as coating sorbent phases and has demonstrated great performance for trace analysis of polar compounds from aqueous media [ 13 , 14 , 15 , 16 , 17 , 18 ]. One of the great advantages of BAμE techniques over other microextraction-based methodologies is that the devices are easily lab-made; they can be prepared in any analytical laboratory.…”

Section: Introductionmentioning

confidence: 99%

Bar Adsorptive Microextraction Coated with Carbon-Based Phase Mixtures for Performance-Enhancement to Monitor Selected Benzotriazoles, Benzothiazoles, and Benzenesulfonamides in Environmental Water Matrices

et al. 2020

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In the present work we propose, for the first time, bar adsorptive microextraction coated with carbon-based phase mixtures, followed by microliquid desorption and high performance liquid chromatography-diode array detection (BAμE-μLD/HPLC-DAD) analysis, to enhance the performance of the determination of traces of benzotriazoles (BTRs), benzothiazoles (BTs), and benzenesulfonamide derivatives (BSDs) in environmental water matrices. Assessing six carbon-based sorbents (CA1, CN1, B test EUR, SX PLUS, SX 1, and R) with different selectivity properties allowed us to tailor the best phase mixture (R, 12.5%/CN1, 87.5%) that has convenient porosity, texture, and surface chemistry (pHPZC,mix ~6.5) for trace analysis of benzenesulfonamide, 1-hydroxybenzotriazole, 1H-benzotriazole, 5-methyl-1H-benzotriazole, benzothiazole, and 1,3-benzothiazol-2-ol chemicals in aqueous media. Optimized experimental conditions provided average recoveries ranging from 37.9% to 59.2%, appropriate linear dynamic ranges (5.0 to 120.0 µg L−1; r2 ≥ 0.9964), limits of detection between 1.0 and 1.4 μg L−1, and good precisions (relative standard deviation (RSD) ≤ 9.3%). The proposed methodology (BAμE(R, 12.5%/CN1, 87.5%)-μLD/HPLC-DAD) also proved to be a suitable sorption-based static microextraction alternative to monitor traces of BTRs, BTs, and BSDs in rain, waste, tap, and estuarine water samples. From the data obtained, the proposed approach showed that the BAμE technique with the addition of lab-made devices allows users to adapt the technique to use sorbents or mixtures of sorbents with the best selectivity characteristics whenever distinct classes of target analytes occur simultaneously in the same application.

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Carbon-Based Sorbent Coatings for the Determination of Pharmaceutical Compounds by Bar Adsorptive Microextraction

Cited by 6 publications

References 46 publications

HS-BAμE: A New Alternative Approach for VOCs Analysis—Application for Monitoring Biogenic Emissions from Tree Species

HS-BAμE: A New Alternative Approach for VOCs Analysis—Application for Monitoring Biogenic Emissions from Tree Species

Application of Bar Adsorptive Microextraction for the Determination of Levels of Tricyclic Antidepressants in Urine Samples

Bar Adsorptive Microextraction Coated with Carbon-Based Phase Mixtures for Performance-Enhancement to Monitor Selected Benzotriazoles, Benzothiazoles, and Benzenesulfonamides in Environmental Water Matrices

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