Carbon Black Functionalized with Naturally Occurring Compounds in Water Phase for Electrochemical Sensing of Antioxidant Compounds

Silveri, Filippo; Pelle, Flavio Della; Scroccarello, Annalisa; Mazzotta, Elisabetta; Giulio, Tiziano Di; Malitesta, Cosimino; Compagnone, Darío

doi:10.3390/antiox11102008

Cited by 16 publications

(5 citation statements)

References 69 publications

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“…[ 53,54 ] Prior to systematic in vitro rats drug delivery experiments, target CLZ was recovered from different real sample environments, including plasma samples, and corresponding serum samples, urine samples, and saliva samples. [ 55 ] As shown in Figure 6D, the recovery for spiked CLZ in all four samples showed high accuracy, and the errors were within acceptable limits, indicating that the sensor was suitable for CLZ testing in the above four samples. In addition, the recovery tests in the four samples above were tested in parallel on four SPE electrodes to verify their stability during continuous testing.…”

Section: Resultsmentioning

confidence: 83%

Domain‐Limited Sub‐Nanometer Co Nanoclusters in Defective Nitrogen Doped Carbon Structures for Non‐Invasive Drug Monitoring

Yu,

Tang,

Gao

et al. 2023

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In this work, sub‐nanometer Co clusters anchored on porous nitrogen‐doped carbon (C─N─Co NCs) are successfully prepared by high‐temperature annealing and pre‐fabricated template strategies for non‐invasive sensing of clozapine (CLZ) as an efficient substrate adsorption and electrocatalyst. The introduction of Co sub‐nanoclusters (Co NCs) provides enhanced electrochemical performance and better substrate adsorption potential compared to porous and nitrogen‐doped carbon structures. Combined with ab initio calculations, it is found that the favorable CLZ catalytic performance with C─N─Co NCs is mainly attributed to possessing a more stable CLZ adsorption structure and lower conversion barriers of CLZ to oxidized state CLZ. An electrochemical sensor for CLZ detection is conceptualized with a wide operating range and high sensitivity, with monitoring capabilities validated in a variety of body fluid environments. Based on the developed CLZ sensing system, the CLZ correlation between blood and saliva and the accuracy of the sensor are investigated by the gold standard method and the rat model of drug administration, paving the way for non‐invasive drug monitoring. This work provides new insights into the development of efficient electrocatalysts to enable drug therapy and administration monitoring in personalized healthcare systems.

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Section: Resultsmentioning

confidence: 83%

Domain‐Limited Sub‐Nanometer Co Nanoclusters in Defective Nitrogen Doped Carbon Structures for Non‐Invasive Drug Monitoring

Yu,

Tang,

Gao

et al. 2023

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“…The chemical nature of the observed nanostructures was confirmed through SEM magnification acquired with an EsB detector (Figure S5A,B), which allows the detection of elements with high molecular weight, , and EDX analysis (Figure S5C–G). Finally, the active role of the CHR paper as a capping/anchoring substrate was confirmed by performing different consecutive water washings of LIMs; these tests were carried out both by immersion in Milli-Q water and by sliding the same over the CHR paper containing the LIMs.…”

Section: Resultsmentioning

confidence: 97%

Single-Stroke Metal Nanoparticle Laser Scribing on Cellulosic Substrates for Colorimetric Paper-Based Device Development

Scroccarello,

Della Pelle,

Di Giulio

et al. 2024

ACS Sustainable Chem. Eng.

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A straightforward CO 2 laser-plotter-based technique to obtain different types of metal nanoparticles on paper is presented. This strategy allows the instantaneous laser-induced generation of metal nanoparticles (LIMs) anchored onto cellulosic substrates with micrometric resolution and customizable patterns; Au, Ag, Pt, Ni, and Cu LIMs have been obtained. LIM features were characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. LIMs are plasmonic-active and characterized by colorimetric features consistent with nanostructure chemistry and density. Arrays of LIMs were assembled in two paper-based formats: (i) a nanocatalytic multimetal comb-shaped device to prove LIMs' remediation ability for the switch-off of organic dyes and (ii) a paper-based nano colorimetric LIM array challenged for peracetic acid (PAA) vapor sensing, useful in the area of environmental sanitization. LIM nanochemistry allows (i) rapid (<1 min) organic dye catalytic conversion and (ii) sensitive PAA detection (LOD ≤ 0.3 μg mL −1 ) capable of discriminating PAA exposure levels from 0.5 to 60 mg m −3 . LIM-based devices returned reproducible data (RSD ≤ 15%, n = 3). Summing up, the proposed strategy is particularly prone to generate catalytic/sensing zones in tailored paper-based devices, resulting in a new sustainable nanopatterning technique appealing in the (bio)sensing and nanochemistry fields.

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“…To further explore the sensors’ electrochemical features, the electroactive surface area (ECSA) of the MNPs@rGO sensors was calculated according to Randles–Sevick’s theory for quasi-reversible systems, , and ECSAs of 8.20 ± 0.60, 10.59 ± 0.91, 11.86 ± 1.96, and 11.85 ± 1.28 mm 2 have been obtained for the rGO, Au@rGO, Ag@rGO, and Pt@rGO, respectively.…”

Section: Resultsmentioning

confidence: 99%

One-Step Laser Nanostructuration of Reduced Graphene Oxide Films Embedding Metal Nanoparticles for Sensing Applications

et al. 2023

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The combination of two-dimensional materials and metal nanoparticles (MNPs) allows the fabrication of novel nanocomposites with unique physical/chemical properties exploitable in high-performance smart devices and biosensing strategies. Current methods to obtain graphene-based films decorated with noble MNPs are cumbersome, poorly reproducible, and difficult to scale up. Herein, we propose a straightforward, versatile, surfactant-free, and single-step technique to produce reduced graphene oxide (rGO) conductive films integrating “naked” noble MNPs. This method relies on the instantaneous laser-induced co-reduction of graphene oxide and metal cations, resulting in highly exfoliated rGO nanosheets embedding gold, silver, and platinum NPs. The production procedure has been optimized, and the obtained nanomaterials are fully characterized; the hybrid nanosheets have been easily transferred onto lab-made screen-printed electrodes preserving their nanoarchitecture. The Au@rGO-, Ag@rGO-, and Pt@rGO-based electrodes have been challenged to detect caffeic acid, nitrite, and hydrogen peroxide in model solutions and real samples. The sensors yielded quantitative responses (R 2 ≥ 0.997) with sub-micromolar limits of detections (LODs ≤ 0.6 μM) for all the analytes, allowing accurate quantification in samples (recoveries ≥ 90%; RSD ≤ 14.8%, n = 3). This single-step protocol which requires low cost and minimal equipment will allow the fabrication of free-standing, MNP-embedded rGO films integrable into a variety of scalable smart devices and biosensors.

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Carbon Black Functionalized with Naturally Occurring Compounds in Water Phase for Electrochemical Sensing of Antioxidant Compounds

Cited by 16 publications

References 69 publications

Domain‐Limited Sub‐Nanometer Co Nanoclusters in Defective Nitrogen Doped Carbon Structures for Non‐Invasive Drug Monitoring

Domain‐Limited Sub‐Nanometer Co Nanoclusters in Defective Nitrogen Doped Carbon Structures for Non‐Invasive Drug Monitoring

Single-Stroke Metal Nanoparticle Laser Scribing on Cellulosic Substrates for Colorimetric Paper-Based Device Development

One-Step Laser Nanostructuration of Reduced Graphene Oxide Films Embedding Metal Nanoparticles for Sensing Applications

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