Carbon–Carbon Bond Forming Reactions in Diazines via Transition-Metal-Catalyzed C–H Bond Activation

Abstract

An overview of the key achievements concerning carbon-carbon bond-forming process with diazines under transition metal-catalyzed C-H activation is presented. Focus is devoted to those examples in which the C-H functionalization takes place in the diazine or the benzodiazine core because of its relevance in material sciences and as active pharmaceutical ingredients. These metal-catalyzed protocols take benefit from the biased reactivity of the C-H bonds targeted or from the presence of a rationally-designed directing group at proximity of the C-H bond to be functionalized. As such, innovative alkylations, alkenylations, alkynylations, arylations and carboxylations are accomplished within such skeletons in a step- and atom-economy fashion.