Carbon Dioxide as a Factor in the Growth of the Tubercle Bacillus and of Other Acidfast Organisms

Rockwell, George E.; Highberger, John H.

doi:10.1093/infdis/38.1.92

Cited by 14 publications

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“…and Erwin (1918) and conclusively proven by Rockwell andHighberger (1926) andby Davies (1940). The CO2 content of atmospheric air is apparently sufficient for the growth of most strains of tubercle bacilli on the classical egg yolk media which contain variable amounts of "free" biotin.…”

Section: Discussionmentioning

confidence: 80%

The Roles of Biotin and Carbon Dioxide in the Cultivation of Mycobacterium Tuberculosis,

1955

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During a study of the growth of tubercle bacilli on primary isolation on oleic acid-albumin agar and on the egg medium of the American Trudeau Society (ATS), the observation was made that a number of strains, which gave growth on ATS medium, did not grow, or grew very poorly, on oleic acid-albumin agar medium (Middlebrook, Cohn, and Schaefer, 1954). In an attempt to improve this latter medium various growth factors were added, and it was found that biotin was either markedly stimulating or even absolutely required for the artificial cultivation of several strains (Middlebrook, Cohn, and Schaefer, 1954). Similarly, incubation under an atmosphere with increased COs content also stimulated the growth of these strains markedly. One strain has been observed for which biotin would not support growth at 37 C, and which was permitted to grow only by incubation under an atmosphere of air containing added C02. The purpose of this paper is to report our observations on the roles of biotin and carbon dioxide as growth factors for tubercle bacilli. MATERIALS AND METHODS The basic oleic acid-albumin agar medium used in these experiments had the following composition: KH2PO4, 1 g; Na,HPO4 (anhydrous), 2.5 g; Nas citrate 2H20, 0.1 g;

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Section: Discussionmentioning

confidence: 80%

The Roles of Biotin and Carbon Dioxide in the Cultivation of Mycobacterium Tuberculosis,

1955

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“…Rockwell and Highberger (1926) investigated the neces sity of carbon dioxide for the growth of several acid-fast organisms and came to the conclusion that carbon dioxide was, in some way, a vital factor in growth. These authors observed inhibition of growth when the organisms were incu bated over alkali in a closed system.…”

Section: Relationship Between Carbon Dioxide and Mycobacteriummentioning

confidence: 99%

“…The necessity of carbon dioxide for the growth of acidfast bacteria has been known for quite some time (Wherry and Ervin, 1918;Rockwell and Highberger, 1926;Masur, 1926;Davies, 1940;Schaefer et al, 1955). The role of carbon dioxide, however, is not well understood.…”

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confidence: 99%

The mechanism of carbon dioxide fixation by the acid-fast organism, Mycobacterium phlei

Myoda

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“…Inhibition of growth by alkali was thought to be due to desiccation and not CO2 removal (Novy and Soule, 1925). Rockwell and Highberger (1926) questioned this conclusion when no inhibition occurred with dehydrating agents that did not absorb CO^. It was sug gested that all bacteria, yeasts, and molds require CO2 as a carbon source (Rockwell and Highberger, 1927).…”

Section: Stimulation Of the Growth Of Heterotrophs By Co2mentioning

confidence: 99%

Assimilation of CO2 by bacteria

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Carbon Dioxide as a Factor in the Growth of the Tubercle Bacillus and of Other Acidfast Organisms

Cited by 14 publications

References 0 publications

The Roles of Biotin and Carbon Dioxide in the Cultivation of Mycobacterium Tuberculosis,

The Roles of Biotin and Carbon Dioxide in the Cultivation of Mycobacterium Tuberculosis,

The mechanism of carbon dioxide fixation by the acid-fast organism, Mycobacterium phlei

Assimilation of CO2 by bacteria

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