Sir,A 72-year-old man without a significant abnormal past medical history underwent an elective laparoscopic right kidney resection. After successful endotracheal intubation, mechanical ventilation was adjusted to maintain P ET CO 2 between 33 and 38 mmHg. Arterial blood gas (ABG) indicated pH 7.44, PaO 2 517 mmHg and PaCO 2 38 mmHg.The patient was then placed in a left lateral decubitus with the head-down (Durant's) position. Pneumoperitoneum was established with CO 2 insufflation to maintain the intra-abdominal pressure (IAP) at 15 mmHg. Unfortunately, the inferior vena cava was incised during dissection and the blood loss was only about 30 ml without any specific surgical interventions. However, central venous pressure (CVP) gradually increased from 7 to 21 mmHg in the following 10 min, whereas BP, HR, SpO 2 and P ET CO 2 remained relatively stable. Precordial auscultation revealed a specific splashing millwheel murmur. Embolism of CO 2 was highly suspected; thus, gas was subsequently aspirated via the central venous catheter. A total volume of 80 ml of gas was obtained after several aspirations; therefore, CO 2 embolism was confirmed. A synchronous ABG indicated pH 7.13, PaCO 2 88 mmHg and PaO 2 305 mmHg. Another 15 ml of gas was aspired after advancing the central venous catheter towards the right atrium; simultaneously, the incision of the inferior vena cava was clipped. Then pneumoperitoneum was terminated and the surgery was suspended. Twenty minutes later, the murmur disappeared and CVP returned to 9 mmHg with stable BP, HR, SpO 2 and P ET CO 2 . Another repeated ABG revealed pH 7.34, PaCO 2 46 mmHg and PaO 2 470 mmHg. Based on these rapid recoveries laparoscopic surgery proceeded smoothly with an IAP 10-12 mmHg. The patient recovered uneventfully without any sequelae.The incidence of clinically significant CO 2 embolism during laparoscopy is rare and its severity depends on the rate and volume of gas entry. 1,2 Durant's position allowed the gas bubble to migrate toward the apex of the heart and away from the pulmonary artery, 2,3 which contributed to the discrepancy of severe CO 2 embolism with few significant signs in this patient. This case report also suggested that BP, HR, SpO 2 and P ET CO 2 are not sensitive surrogates in detecting CO 2 embolism in some cases.