Carbon dioxide laser skin resurfacing with a cooled handpiece

Moore, Brian A.; Daamen, Nicole; Biesman, Brian S.; Reinisch, Lou

doi:10.1002/lsm.1113

Cited by 1 publication

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While clippings can be trimmed to flatten the curvature of the nail, variation in microporation is to be expected when implementing LAUD in a clinical setting. Flattening the nail plate using a CO 2 ‐laser transmissive optical window made of zinc selenide could present a convenient alternative that merits further investigation 57 …”

Section: Discussionmentioning

confidence: 99%

“…Flattening the nail plate using a CO 2 -laser transmissive optical window made of zinc selenide could present a convenient alternative that merits further investigation. 57 The current treatment paradigm for OM rests on pharmacological management with either topically or orally administered antifungal agents. While laser therapy of OM has only been cleared by the US Food and Drug Administration (FDA) for "temporary increase in clear nail," 58 in-office laser treatments may prove beneficial for patients where medication adherence or systemic interactions are a concern.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fractional CO₂ laser ablation leads to enhanced permeation of a fluorescent dye in healthy and mycotic nails—An imaging investigation of laser–tissue effects and their impact on ungual drug delivery

et al. 2022

View full text Add to dashboard Cite

Conventional oral antifungal therapies for onychomycosis (OM) often do not achieve complete cure and may be associated with adverse effects, medical interactions, and compliance issues restricting their use in a large group of patients. Topical treatment can bypass the systemic side effects but is limited by the physical barrier of the nail plate. Ablative fractional laser (AFL) treatment can be used to improve the penetration of topical drugs into the nail. This study visualized the effects of laser ablation of nail tissue and assessed their impact on the biodistribution of a fluorescent dye in healthy and fungal nail tissue. Methods: For the qualitative assessment of CO 2 AFL effects on healthy nail tissue, scanning electron microscopy (SEM), coherent anti-Stokes Raman scattering microscopy (CARS-M), and widefield fluorescence microscopy (WFM) were used. To quantitate the effect of laser-pretreatment on the delivery of a fluorescent dye, ATTO-647N, into healthy and fungal nail tissue, ablation depth, nail plate thickness, and ATTO-647N fluorescence intensity in three nail plate layers were measured using WFM. A total of 30 nail clippings (healthy n = 18, fungal n = 12) were collected. An aqueous ATTO-647N solution was directly applied to the dorsal surface of 24 nail samples (healthy n = 12, fungal n = 12) and incubated for 4 hours, of which half (healthy n = 6, fungal n = 6) had been pretreated with AFL (30 mJ/mb, 15% density, 300 Hz, pulse duration <1 ms). Results: Imaging revealed a three-layered nail structure, an AFL-induced porous ablation crater, and changes in autofluorescence. While intact fungal samples showed a 106% higher ATTO-647N signal intensity than healthy controls, microporation led to a significantly increased fluorophore permeation in all samples (p < 0.0001). AFL processing of nail tissue enhanced topical delivery of ATTO-647N in all layers, (average increase: healthy +108%, fungal +33%), most pronounced in the top nail layer (healthy +122%, fungal +68%). While proportionally deeper ablation craters correlated moderately with higher fluorescence intensities in healthy nail tissue, fungal samples showed no significant relationship. Conclusion: Fractional CO 2 laser microporation is a simple way of enhancing the passive delivery of topically applied ATTO-647N. Although the impaired nail

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fractional CO₂ laser ablation leads to enhanced permeation of a fluorescent dye in healthy and mycotic nails—An imaging investigation of laser–tissue effects and their impact on ungual drug delivery

et al. 2022

View full text Add to dashboard Cite

show abstract

Carbon dioxide laser skin resurfacing with a cooled handpiece

Abstract: There is no significant advantage in using a cooled or room temperature zinc selenide handpiece for epithelial preservation or decreasing the inflammatory response in CO(2) laser resurfacing.

Cited by 1 publication

References 11 publications

Fractional CO₂ laser ablation leads to enhanced permeation of a fluorescent dye in healthy and mycotic nails—An imaging investigation of laser–tissue effects and their impact on ungual drug delivery

Fractional CO₂ laser ablation leads to enhanced permeation of a fluorescent dye in healthy and mycotic nails—An imaging investigation of laser–tissue effects and their impact on ungual drug delivery

Contact Info

Product

Resources

About

Carbon dioxide laser skin resurfacing with a cooled handpiece

Abstract: There is no significant advantage in using a cooled or room temperature zinc selenide handpiece for epithelial preservation or decreasing the inflammatory response in CO(2) laser resurfacing.

Cited by 1 publication

References 11 publications

Fractional CO2 laser ablation leads to enhanced permeation of a fluorescent dye in healthy and mycotic nails—An imaging investigation of laser–tissue effects and their impact on ungual drug delivery

Fractional CO2 laser ablation leads to enhanced permeation of a fluorescent dye in healthy and mycotic nails—An imaging investigation of laser–tissue effects and their impact on ungual drug delivery

Contact Info

Product

Resources

About

Fractional CO₂ laser ablation leads to enhanced permeation of a fluorescent dye in healthy and mycotic nails—An imaging investigation of laser–tissue effects and their impact on ungual drug delivery

Fractional CO₂ laser ablation leads to enhanced permeation of a fluorescent dye in healthy and mycotic nails—An imaging investigation of laser–tissue effects and their impact on ungual drug delivery