Carbon disulfide

Khalid, Madiha; Moradkhan, Fatemeh Matin; Bayrami, Zahra

doi:10.1016/b978-0-12-824315-2.00562-5

Encyclopedia of Toxicology 2024

DOI: 10.1016/b978-0-12-824315-2.00562-5

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Carbon disulfide

Madiha Khalid

Fatemeh Matin Moradkhan

Zahra Bayrami

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2024

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Cited by 2 publications

References 81 publications

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Bioorthogonal Delivery of Carbon Disulfide in Living Cells

Zhao,

Chen,

Liang

2024

Angewandte Chemie

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Carbon disulfide (CS2) is an environmental pollutant, which is deadly hazardous to the workers under chronic or acute exposure. However, the toxicity mechanisms of CS2 are still unclear due to the scarcity of biocompatible donors, which can release CS2 in cells. Here we developed the first bioorthogonal CS2 delivery system based on the “click‐and‐release” reactions between mesoionic 1,3‐thiazolium‐5‐thiolates (TATs) and strained cyclooctyne exo‐BCN‐OH. We successfully realized intracellular CS2 releasing and investigated the causes of CS2‐induced hepatotoxicity, including oxidative stress, proteotoxic stress and copper‐dependent cell death. It is found that CS2 can be copper vehicles bypassing copper transporters after reacting with nucleophiles in cytoplasm, and extra copper supplementation will exacerbate the loss of homeostasis of cells and ultimately cell death. These findings inspired us to explore the anticancer activity of CS2 in combination with copper by introducing a copper chelating group in our CS2 delivery system.

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Bioorthogonal Delivery of Carbon Disulfide in Living Cells

Zhao,

Chen,

Liang

2024

Angewandte Chemie

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Bioorthogonal Delivery of Carbon Disulfide in Living Cells

Zhao,

Chen,

Liang

2024

Angew Chem Int Ed

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Carbon disulfide

Cited by 2 publications

References 81 publications

Bioorthogonal Delivery of Carbon Disulfide in Living Cells

Bioorthogonal Delivery of Carbon Disulfide in Living Cells

Bioorthogonal Delivery of Carbon Disulfide in Living Cells

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