“…[34][35][36][37] Among attractive carbon nanomaterials, uorescent carbon dots (CDs) of sizes less than 10 nm are widely used as promising uorescent sensors in biological imaging and as photodynamic therapy tools in consideration of their unique optical, chemical, and biological performances mentioned above as carbon-based nanoparticles. [38][39][40][41][42] However, despite these attractive properties, most reported CDs generally emit blue or green uorescence with low uorescence quantum yield and stability, which not only suffer from strong auto-uorescence and background interference in biological systems, but also cause radiation damage to tissues and cells. 40,43 As a consequence, the design and development of red/near-infrared (NIR) emissive CDs are interesting and attractive, and have also drawn tremendous attention because of certain advantages, including low levels of light scattering/absorption, long-wavelength emission, deep tissue penetration and negligible auto-uorescence interference from the biological background.…”