Carbon dots and gold nanoparticles doped metal-organic frameworks as high-efficiency ECL emitters for monitoring of cell apoptosis

Advances in electrochemiluminescence for single-cell analysis

“…A strategy of embedding zero-dimensional CDs into the skeletal network of metal nanosheets could provide an ingenious solution to this problem. 82,83 Metal NCs are usually composed of tens of metal atoms, are ultra-small in size (<2 nm), and act as a bridge between organometallic compounds and crystalline metal NPs, and thus have potential applications in the field of single-cell analysis. 84–86…”

Recent advances in DNA-based electrogenerated chemiluminescence biosensors

“…Caspase-3 plays an irreplaceable role in apoptosis, and thus is an important biomarker for monitoring apoptosis. 129 Liang et al 130 prepared a high-efficiency ECL emitter by doping carbon dots (CDots) and AuNPs in ZIF-8. CDots@ZIF-8/AuNPs not only acted as a carrier for the ECL luminophore, but also a co-reactant to enhance the signal.…”

Plasmon-Enhanced Electrochemiluminescence of PTP-Decorated Eu MOF-Based Pt-Tipped Au Bimetallic Nanorods for the Lincomycin Assay

“…Electrochemiluminescence (ECL), a product of cross-penetration between electrochemistry and chemiluminescence, provides the ultrahigh sensitivity of luminescence analysis with the advantages of controllable electrochemical potential, high sensitivity, and low background signal. − Recently, ECL has attracted attention in early clinical diagnosis, environmental monitoring, and food safety. − For example, a sensitive ECL biosensor was constructed by synthesizing anode ECL self-catalyzed carbon dots for microRNA detection . An electrochemiluminescent immunosensor was designed for ultrasensitive detection of diclofenac based on a multiple signal amplification strategy of palladium-attached graphene oxide and ceria-doped zinc oxide .…”