Carbon Dots as Potent Antimicrobial Agents

Dong, Xiuli; Liang, Weixiong; Meziani, Mohammed J.; Sun, Ya‐Ping; Yang, Liju

doi:10.7150/thno.39863

Cited by 294 publications

(212 citation statements)

References 96 publications

Supporting

Mentioning

203

Contrasting

Unclassified

Order By: Relevance

“…In the study, the CDots with 2,2 0 -(ethylenedioxy)bis(ethylamine) (EDA) for the carbon nanoparticle surface functionalization (thus EDA-CDots, Fig. 1) were selected for their being chemically and structurally well characterized 37 and effective in antibacterial activities against multiple laboratory model bacteria, 32,33,36,38 as well as exhibiting signicant antiviral potential in the initial evaluation of their inhibitory effect on the binding of norovirus VLPs to host cell receptor. 39 The use of bacteriophage MS2 in this study was to further reveal the effect of CDots on viral infectivity and viral genome, and to explore mechanistic insights into the action of CDots on the virus, both of which would not be possible with the VLPs.…”

Section: Introductionmentioning

confidence: 99%

Carbon dots for effective photodynamic inactivation of virus

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Carbon dots for effective photodynamic inactivation of virus

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Carbon nanodots or carbon quantum dots were originally discovered due to their bright fluorescence emissions as those found in conventional semiconductor quantum dots, and can also be used for drug delivery [116]. Carbon dots modified with vancomycin were proposed for the treatment of Gram-positive bacterial infections [117].…”

Section: Other Nanostructures For Amp Deliverymentioning

confidence: 99%

Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)

et al. 2020

View full text Add to dashboard Cite

Microbial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. Antimicrobial resistance rate is fostering the need to develop new strategies against drug-resistant superbugs. Antimicrobial peptides (AMPs) are small peptide-based molecules of 5-100 amino acids in length, with potent and broad-spectrum antimicrobial properties. They are part of the innate immune system, which can represent a minimal risk of resistance development. These characteristics contribute to the description of these molecules as promising new molecules in the development of new antimicrobial drugs. However, efforts in developing new medicines have not resulted in any decrease of drug resistance yet. Thus, a technological approach on improving existing drugs is gaining special interest. Nanomedicine provides easy access to innovative carriers, which ultimately enable the design and development of targeted delivery systems of the most efficient drugs with increased efficacy and reduced toxicity. Based on performance, successful experiments, and considerable market prospects, nanotechnology will undoubtedly lead a breakthrough in biomedical field also for infectious diseases, as there are several nanotechnological approaches that exhibit important roles in restoring antibiotic activity against resistant bacteria.

show abstract

“…Functional carbon dots as antiviral agents: Several antiviral therapeutics are recently being developed around the World, based on carbon dots or carbon quantum dots, initially discovered for its colorful and bright fluorescence resembling the conventional semiconductor quantum dots [49] , [53] , [54] , [55] .…”

Section: Nanomaterials As Viral Entry Inhibitorsmentioning

confidence: 99%