Carbon dots derived fromFusobacterium nucleatumfor intracellular determination of Fe3+and bioimaging bothin vitroandin vivo

Lou, Lijuan; Zhang, Shengting; Zheng, Xiaodan; Li, Hongmei; Chen, Qi; Qin, Kunhao; Ding, Yafang; Wei, Yunlin

doi:10.1039/d1ay00020a

Cited by 24 publications

(15 citation statements)

References 38 publications

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“…However, an excess of iron ions can lead to toxicity, cardiac disorders, liver cancer, diabetes, intellectual disability, thyroid disorders and even death. By contrast, iron deficiency can cause anaemia, require frequent transfusions and induce chronic hepatitis [4–6]. To avert those conditions, iron solutions and tablets are often used as food supplements [7].…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Method for Determining Ferric Ions with Quercetin

et al. 2021

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A novel, simple, rapid, inexpensive, highly sensitive voltammetric method developed for determining ferric ions with quercetin in water samples and iron supplements using a disposable bare pencil graphite electrode is described. The limit of detection and analytical ranges for the ferric ions were 3.6 nM and 17.9–716.0 nM, respectively. The results with the water samples were compared with those obtained from a potentiometric auto‐titration system, and the method's accuracy was tested using certified reference material. The complex stoichiometry and electrode reaction were also systematically investigated with UV‐visible spectrophotometry, 1H‐NMR spectroscopy and voltammetry.

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Section: Introductionmentioning

confidence: 99%

Voltammetric Method for Determining Ferric Ions with Quercetin

et al. 2021

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“…The outstanding selectivity and sensitivity of the prepared CQDsbased sensor demonstrated potential application in Fe 3+ detection in acidic environments (pH = 0) with an obtained LOD = 0.96 µM. Another interesting example is the study of the Liu et al [88] with N-CQDs fabrication from Fusobacterium nucleatum, which is an anaerobic Gram-positive oral commensal bacteria that was a single precursor for the hydrothermal synthesis of N-CQDs at 180 • C for 12 h. The selectivity measurements showed the selective response toward Fe 3+ ions, and a good linear response was obtained within the linear concentration range from 20 to 180 µM with an obtained R 2 = 0.9855. The estimated LOD was 0.82 µM.…”

Section: Ferric (Fe 3+ ) Ions Detectionmentioning

confidence: 99%

An Overview of the Recent Developments in Carbon Quantum Dots—Promising Nanomaterials for Metal Ion Detection and (Bio)Molecule Sensing

et al. 2021

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The fluorescent carbon quantum dots (CQDs) represent an emerging subset of carbonaceous nanomaterials, recently becoming a powerful tool for biosensing, bioimaging, and drug and gene delivery. In general, carbon dots are defined as zero-dimensional (0D), spherical-like nanoparticles with <10 nm in size. Their unique chemical, optical, and electronic properties make CQDs versatile materials for a wide spectrum of applications, mainly for the sensing and biomedical purposes. Due to their good biocompatibility, water solubility, and relatively facile modification, these novel materials have attracted tremendous interest in recent years, which is especially important for nanotechnology and nanoscience expertise. The preparation of the biomass-derived CQDs has attracted growing interest recently due to their low-cost, renewable, and green biomass resources, presenting also the variability of possible modification for the enhancement of CQDs’ properties. This review is primarily focused on the recent developments in carbon dots and their application in the sensing of different chemical species within the last five years. Furthermore, special emphasis has been made regarding the green approaches for obtaining CQDs and nanomaterial characterization toward better understanding the mechanisms of photoluminescent behavior and sensing performance. In addition, some of the challenges and future outlooks in CQDs research have been briefly outlined.

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“…The low cytotoxicity of CNDs as compared to SQDs allows their use in bioimaging in vitro and vivo, which opens many possibilities in nanomedicine [3,[76][77][78][79][80][81][82][83][84][85][86][87]. With their high quantum yield and excitation-dependent emission, CNDs can be used for multicolor imaging in specific cells or organs.…”

Section: Bioimagingmentioning

confidence: 99%

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

Khan

Dunphy

Anike

et al. 2021

IJMS

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Carbon nanodots (CNDs) are an emerging class of nanomaterials and have generated much interest in the field of biomedicine by way of unique properties, such as superior biocompatibility, stability, excellent photoluminescence, simple green synthesis, and easy surface modification. CNDs have been featured in a host of applications, including bioimaging, biosensing, and therapy. In this review, we summarize the latest research progress of CNDs and discuss key advances in our comprehension of CNDs and their potential as biomedical tools. We highlighted the recent developments in the understanding of the functional tailoring of CNDs by modifying dopants and surface molecules, which have yielded a deeper understanding of their antioxidant behavior and mechanisms of action. The increasing amount of in vitro research regarding CNDs has also spawned interest in in vivo practices. Chief among them, we discuss the emergence of research analyzing CNDs as useful therapeutic agents in various disease states. Each subject is debated with reflection on future studies that may further our grasp of CNDs.

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Carbon dots derived fromFusobacterium nucleatumfor intracellular determination of Fe³⁺and bioimaging bothin vitroandin vivo

Abstract: Intracellular Fe3+ amount is one of critical determinants of human health. The development of simple and effective probes for quantitative detection of Fe3+ in vivo is of great significance for...

Cited by 24 publications

References 38 publications

Voltammetric Method for Determining Ferric Ions with Quercetin

Voltammetric Method for Determining Ferric Ions with Quercetin

An Overview of the Recent Developments in Carbon Quantum Dots—Promising Nanomaterials for Metal Ion Detection and (Bio)Molecule Sensing

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

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