Carbon Dots Doped with Dysprosium: A Bimodal Nanoprobe for MRI and Fluorescence Imaging

Atabaev, Timur Sh.; Piao, Zhonglie; Molkenova, Anara

doi:10.3390/jfb9020035

Cited by 14 publications

(5 citation statements)

References 18 publications

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“…It is worth noting that dysprosium (Dy) element with a large effective magnetic moment (10.6 μ B ) and shorter electron relaxation time (0.5 ps) plays an important role in T2-weighted MRI [28]. Due to the free Dy 3+ ion has strong toxicity, many complexes based on Dy have been prepared as T2 contrast agents [29][30][31]. Moreover, owing to the high atomic number (66), strong x-ray attenuation coefficient (3.36 cm 2 g −1 at 100 keV), and substantial K-edge value (53.8 keV) of Dy 3+ , several Dy complexes are also expected to be a functional contrast agent for CT imaging [28].…”

Section: Introductionmentioning

confidence: 99%

Manganese and dysprosium codoped carbon quantum dots as a potential fluorescent/T1/T2/CT quadri-modal imaging nanoprobe

Li¹,

Wang²,

Nong³

et al. 2021

Nanotechnology

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It has been challenging to integrate various medical imaging modalities into an ultra-small nanoparticle with good biocompatibility to build highly efficient multimodal imaging nanoprobes. A new manganese and dysprosium codoped carbon quantum dots (Mn,Dy-CQDs) with a mean diameter of 1.77 nm was synthesized for fluorescence imaging, T1/T2-weighted magnetic resonance imaging (T1/T2-weighted MRI), and x-ray computed tomography (CT) imaging using a simple onestep hydrothermal approach. The obtained Mn,Dy-CQDs showed good water solubility, long-term stability, strong stable fluorescence property (fluorescence quantum yield of 31.62%), and excellent biocompatibility. The cell imaging verified that the Mn,Dy-CQDs have high efficiency of fluorescence imaging. The Mn,Dy-CQDs, on the other hand, had a superior x-ray absorption performance (47.344 HU l g −1 ), a higher longitudinal relaxivity (r 1 =7.47 mM −1 s −1 ), a higher transverse relaxivity (r 2 =42.686 mM −1 s −1 ). In vitro T1/T2-weighted MRI and CT imaging showed that Mn,Dy-CQDs can produce a strong contrast enhancement impact. To summarise, the Mn,Dy-CQDs may be used as a T1/T2-weighted MRI/CT/fluorescent quadri-modal imaging nanoprobe, indicating that they have a lot of uses in biomedical multimode imaging and clinics.

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Section: Introductionmentioning

confidence: 99%

Manganese and dysprosium codoped carbon quantum dots as a potential fluorescent/T1/T2/CT quadri-modal imaging nanoprobe

Li¹,

Wang²,

Nong³

et al. 2021

Nanotechnology

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“…It not only improves the optical properties of CDs, but also increases their magnetic relaxation properties. In addition, it has been shown that the toxicity of metal ions existing in CDs in chelated form can be greatly reduced, so magnetic CDs also have good biocompatibility, which gives them excellent potential for application in tumor theranostics. − …”

Section: Properties Of Magnetic Cdsmentioning

confidence: 99%

Advances in Magnetic Carbon Dots: A Theranostics Platform for Fluorescence/Magnetic Resonance Bimodal Imaging and Therapy for Tumors

Zhong,

Chen,

et al. 2023

ACS Biomater. Sci. Eng.

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Theranostics technology that combines tumor diagnosis or monitoring with therapy is an important direction for the future development of tumor treatment. It takes advantage of efficiently observing tumor tissues, monitoring tumor treatment in real time, and significantly improving the cure efficiency. Magnetic carbon dots (CDs) are of wide interest as molecular imaging probes, drug carriers, photosensitizers, and radiosensitizers in the integration of tumor fluorescence/magnetic resonance bimodal diagnosis and treatment because of their small size, good optical stability, magnetic relaxation rate, and biocompatibility. This review first analyzes and compares the synthesis methods and physicochemical properties of magnetic CDs in recent years and then concludes their mechanism in tumor fluorescence/magnetic resonance bimodal imaging and therapy in details. Subsequently, the research progress of their application in tumor theranostics are summarized. Finally, the problems and challenges of magnetic CDs for development at this stage are prospected. This review provides new ideas for their controlled synthesis and application in efficient and precise therapy for tumors.

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“…CDs doped with dysprosium for a magneto-fluorescent bimodal imaging agent showed strong blue-green fluorescence at 452 nm. The excellent transverse relaxivity r 2 makes them also suitable for T 2 weighted imaging of live cells [66].…”

Section: Fluorescence/magnetic Resonance Imagingmentioning

confidence: 99%

Naturally Derived Carbon Dots as Bioimaging Agents

Gedda¹,

Bhupathi²,

Tiruveedhi³

2021

Biomechanics and Functional Tissue Engineering

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The recent advances in nanoscience and technology have opened new avenues for carbon-based nanomaterials. Especially, Carbon dots (CDs) have gained significant attention due to their simple, economic and rapid green synthesis. These materials exhibit excellent water solubility, fluorescence emission, high fluorescence quantum yield, Ultraviolet (UV) to Infrared (IR) range absorbance and high bio-compatibility. Therefore, these materials are widely used for various biological applications including bio-imaging. With the integration and doping of surface passive agents and elements, respectively influenced the enhancement of fluorescence property of CDs. Also, the conjugation of receptor-based targeting ligands leads to targeted bioimaging. CDs in combination with other imaging contrast agents lead to the development of novel contrast agents for bimodal imaging and multimodal imaging techniques. The combination of diagnostic CDs with therapeutic agents resulted in the formation of theragnostic CDs for image guided therapies. In this chapter, a comprehensive view on the top-down and bottom–up green synthesis methods for naturally derived CDs discussed. Further, unique physical, chemical, optical and biological properties of CDs described. Finally, fluorescence based bimodal and multimodal imaging techniques also described.

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Carbon Dots Doped with Dysprosium: A Bimodal Nanoprobe for MRI and Fluorescence Imaging

Cited by 14 publications

References 18 publications

Manganese and dysprosium codoped carbon quantum dots as a potential fluorescent/T1/T2/CT quadri-modal imaging nanoprobe

Manganese and dysprosium codoped carbon quantum dots as a potential fluorescent/T1/T2/CT quadri-modal imaging nanoprobe

Advances in Magnetic Carbon Dots: A Theranostics Platform for Fluorescence/Magnetic Resonance Bimodal Imaging and Therapy for Tumors

Naturally Derived Carbon Dots as Bioimaging Agents

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