Carbon fiber ionization mass spectrometry coupled with solid phase microextraction for analysis of Benzo[a]pyrene

Wu, Min; Chen, Te Yu; Chen, Wen Jie; Baig, Mirza Muhammad Fahad; Yi, Wu; Chen, Yu-Chie

doi:10.1016/j.aca.2018.10.037

Cited by 15 publications

(12 citation statements)

References 35 publications

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“…The mechanism for Pb 2+ sorption on carbon is primarily via the electrostatic interaction between Pb 2+ and negative charges, such as −COO – , on the surfaces, resulted from the deprotonation of its oxygen-containing functional groups. , For example, after Pb 2+ sorption, IR bands corresponding to −COOH or –OH are weakened. , The complexation between the acidic surface functional groups of carbon particles with other metals is likely through the similar mechanism . Besides, carbon particle has high affinity toward polycyclic aromatic hydrocarbons via hydrophobic interactions due to the graphite-like surface structure of carbon particles. , …”

Section: Resultsmentioning

confidence: 99%

“…31 Besides, carbon particle has high affinity toward polycyclic aromatic hydrocarbons via hydrophobic interactions due to the graphite-like surface structure of carbon particles. 33,34 Model PM 2.5 particles were prepared by incubating pollutant solutions with carbon particles. Particles were separated from solution and washed.…”

Section: Environmental Science and Technologymentioning

confidence: 99%

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Induction of Inflammatory Responses in Human Bronchial Epithelial Cells by Pb²⁺-Containing Model PM_2.5 Particles via Downregulation of a Novel Long Noncoding RNA lnc-PCK1-2:1

Pan

Yuan

et al. 2019

Environ. Sci. Technol.

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Airborne particular matter (PM2.5) contains complex mixtures of pollutants, and their compositions also vary with time and location. Inhalation of PM2.5 may cause a number of diseases, such as bronchial and lung inflammation and lung cancer. So far, how different components of PM2.5 contribute to inflammation and toxicity is still not known. To identify key PM2.5 components that are responsible for inflammation, here we took a reductionism approach and synthesized a model PM2.5 library containing 20 carbon nanoparticle based members with loadings of As(III), Pb2+, Cr(VI), and BaP individually or in combination at environment relevant concentrations. We discovered that only carbon nanoparticle–Pb2+ adducts, not other pollutants or adducts, induced inflammation in human bronchial cells by suppressing the expression of a novel long noncoding RNA lnc-PCK1-2:1, while lnc-PCK1-2:1 routinely plays a regulatory role in inhibiting inflammation. This finding was further substantiated by varying Pb2+ loadings on carbon nanoparticles and overexpressing lnc-PCK1-2:1. The success of this approach opens an avenue for further elucidation of molecular mechanisms of PM2.5-induced inflammation and toxicity.

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Section: Resultsmentioning

confidence: 99%

Section: Environmental Science and Technologymentioning

confidence: 99%

Induction of Inflammatory Responses in Human Bronchial Epithelial Cells by Pb²⁺-Containing Model PM_2.5 Particles via Downregulation of a Novel Long Noncoding RNA lnc-PCK1-2:1

Pan

Yuan

et al. 2019

Environ. Sci. Technol.

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“…Nevertheless, considering that most mass spectrometers are usually equipped with a high electric field, ionization might occur on the basis of induction by the electric field provided by the mass spectrometer. Thus, field-induced electrospray ionization (ESI) − and field-induced atmospheric pressure chemical ionization − have been explored. No additional electric voltage or contact was made on the ionization emitter.…”

Section: Introductionmentioning

confidence: 99%

“…No additional voltages were required for MAI to occur. Most of these existing ionization techniques still need small accessories such as capillaries, ,,, carbon fibers, ,− or a matrix for the facilitation of ionization of analytes. The elimination of these small accessories can further simplify ionization methods.…”

Section: Introductionmentioning

confidence: 99%

Direct Mass Spectrometric Analysis of Semivolatiles Derived from Real Samples at Atmospheric Pressure

2022

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This study demonstrated a facile ionization method with the use of real samples for the ionization of their main compositions at ambient conditions for mass spectrometric analysis. Analyte ions derived from the real samples were readily observed in the mass spectrum when placing the samples close (≤1 mm) to the inlet of the mass spectrometer applied with a high voltage. No additional accessories such as an ionization emitter, a plasma generator, or a high voltage power supply were required for this approach. Ionization of semivolatiles derived from the samples occurred between the samples and the inlet of the mass spectrometer presumably owing to the dielectric breakdown induced by the electric field provided by the mass spectrometer. Real samples including plants, medicine tablets, and gloves with contaminants were used as the model samples. The putative ionization mechanisms are also discussed in this study.

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“…In recent years, microscale extraction-based sample cleanup methods that can be directly coupled with ambient mass spectrometry analysis , have become increasingly important for rapid and portable chemical analysis. Among these methods, solid phase microextraction (SPME), first established by Pawliszyn et al, has gained traction within the scientific community because of its simplicity, low sample/solvent consumption, and compatibility to other sample processing techniques. − In recent years, the development of a biocompatible SPME probe that allows direct extraction of target analytes from complex biological matrices has become an increasingly important tool for many bioanalytical applications. , …”

Section: Introductionmentioning

confidence: 99%

A Small Footprint and Robust Interface for Solid Phase Microextraction and Mass Spectrometry Based on Vibrating Sharp-Edge Spray Ionization

Wang

2022

J. Am. Soc. Mass Spectrom.

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Combining solid phase microextraction (SPME) and mass spectrometry (MS) analysis has become increasingly important to many bioanalytical, environmental, and forensic applications due to its simplicity, rapid analysis, and capability of reducing matrix effects for complex samples. To further promote the adoption of SPME-MS based analysis and expand its application scope calls for efficient and convenient interfaces that couple the SPME sample handling with the efficient analyte ionization for MS. Here, we report a novel interface that integrates both the desorption and the ionization steps in one device based on the capillary vibrating sharp-edge spray ionization (cVSSI) method. We demonstrated that the cVSSI is capable of nebulizing liquid samples in a pulled-tip glass capillary with a battery powered function generator. The cVSSI device allows the insertion of a SPME probe into the spray capillary for desorption and then direct nebulization of the desorption solvent in situ. With the integrated interface, we have demonstrated rapid MS analysis of drug compounds from serum samples. Quantitative determination of various drug compounds including metoprolol, pindolol, acebutolol, oxprenolol, capecitabine, and irinotecan was achieved with good linearity (R 2 = 0.97–0.99) and limit of detection ranging from 0.25 to 0.59 ng/mL without using a high voltage source. Only 3.5 μL of desorption solvent and 3 min desorption time were needed for the present method. Overall, we demonstrated a portable SPME-MS interface featuring high sensitivity, short analysis time, small footprint, and low cost, which makes it an attractive method for many applications requiring sample cleanup including drug compound monitoring, environmental sample analysis, and forensic sample analysis.

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Carbon fiber ionization mass spectrometry coupled with solid phase microextraction for analysis of Benzo[a]pyrene

Cited by 15 publications

References 35 publications

Induction of Inflammatory Responses in Human Bronchial Epithelial Cells by Pb²⁺-Containing Model PM_2.5 Particles via Downregulation of a Novel Long Noncoding RNA lnc-PCK1-2:1

Induction of Inflammatory Responses in Human Bronchial Epithelial Cells by Pb²⁺-Containing Model PM_2.5 Particles via Downregulation of a Novel Long Noncoding RNA lnc-PCK1-2:1

Direct Mass Spectrometric Analysis of Semivolatiles Derived from Real Samples at Atmospheric Pressure

A Small Footprint and Robust Interface for Solid Phase Microextraction and Mass Spectrometry Based on Vibrating Sharp-Edge Spray Ionization

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Carbon fiber ionization mass spectrometry coupled with solid phase microextraction for analysis of Benzo[a]pyrene

Cited by 15 publications

References 35 publications

Induction of Inflammatory Responses in Human Bronchial Epithelial Cells by Pb2+-Containing Model PM2.5 Particles via Downregulation of a Novel Long Noncoding RNA lnc-PCK1-2:1

Induction of Inflammatory Responses in Human Bronchial Epithelial Cells by Pb2+-Containing Model PM2.5 Particles via Downregulation of a Novel Long Noncoding RNA lnc-PCK1-2:1

Direct Mass Spectrometric Analysis of Semivolatiles Derived from Real Samples at Atmospheric Pressure

A Small Footprint and Robust Interface for Solid Phase Microextraction and Mass Spectrometry Based on Vibrating Sharp-Edge Spray Ionization

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Product

Resources

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Induction of Inflammatory Responses in Human Bronchial Epithelial Cells by Pb²⁺-Containing Model PM_2.5 Particles via Downregulation of a Novel Long Noncoding RNA lnc-PCK1-2:1

Induction of Inflammatory Responses in Human Bronchial Epithelial Cells by Pb²⁺-Containing Model PM_2.5 Particles via Downregulation of a Novel Long Noncoding RNA lnc-PCK1-2:1