Carbon–Halogen Bond Formation

Base-Mediated Synthesis of 2-Bromobenzoheterocycles

“…1 2 3 Beyond their prominence in the fields of medicinal, materials, and agricultural chemistry, the presence of a halogen provides potential for further functionalization and a simple approach to expand molecular diversity. 4,5 Some halogenated heterocycles can be particularly challenging to synthesize, and thus, new methods to access these molecules have remained a topic of ongoing study.…”

Photoexcited Nickel-Catalyzed Carbohalogenation

“…The development of efficient reactions to forge C–X bonds remains an important objective resulting from the diversity of their subsequent transformations. − Gaining insight into mechanistic aspects of these transformations provides important details on key intermediates that can be applied in future reaction design. , Addressing previous limitations with these methodologies allows for the development of simpler, cost-effective, and scalable protocols . This report details our successful efforts in understanding and addressing limitations of a reaction involving C–X bond formation.…”