Carbon Ion Radiation Therapy for Primary Renal Cell Carcinoma: Initial Clinical Experience

Nomiya, Takuma; Tsuji, Hiroshi; Hirasawa, Naoki; Kato, Hiroyuki; Kamada, Tadashi; Mizoe, Jun‐etsu; Kishi, Hirohisa; Kamura, Kouichi; Wada, Hitoshi; Nemoto, Kenji; Tsujii, Hirohiko

doi:10.1016/j.ijrobp.2008.01.043

Cited by 60 publications

(57 citation statements)

References 21 publications

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“…The National Institute of Radiological Sciences in Japan also did not use 4D CT imaging for target delineation. Instead, a margin of 15-20 mm was added to the GTV and used alongside iridium needles for target verification (52). One report from the Methodist Hospital in Houston (53) described the use of 4DCT in the planning process, however, this was for treatment using a gating technique.…”

Section: Discussionmentioning

confidence: 99%

A Review of Kidney Motion under Free, Deep and Forced-Shallow Breathing Conditions: Implications for Stereotactic Ablative Body Radiotherapy Treatment

Pham

Kron

Foroudi

et al. 2014

Technol Cancer Res Treat

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Motion management strategies are important during stereotactic ablative body radiotherapy for abdominal targets. The kidney is a mobile retroperitoneal organ that moves with respiration. A review of the literature was performed to investigate the reported degree of kidney motion associated with various breathing conditions. A structured search was performed using Medline from January 1970 to May 2013 for all publications describing cranial-caudal kidney motion. Relevance to radiotherapy practice was reviewed based on any breathing instructions and/or immobilization equipment that could affect breathing pattern. Studies were categorized under three types of breathing conditions: Forced-shallow, breath-hold/ deep and free. A total of 25 publications were identified describing cranial-caudal kidney motion with a combined total of 415 participants. Three publications described forced-shallow breathing using prone positioning or abdominal compression plates. Prone positioning, compared to supine positioning, did little to minimise kidney motion, however use of compression plates can result in kidney motion of less than 5 mm. Eight publications described deep breathing/breath hold techniques that showed average kidney motion ranging between 10 mm-40 mm. Fifteen publications investigated kidney motion under free breathing with the majority reporting mean motion of less than 10 mm. Kidney movement of up to 8.1 mm in the anterior posterior direction and 6.2 mm laterally were reported with no indications that breathing technique can influence the extent of this motion. In summary, kidney movement is complex and consideration should be made to ensure that motion management strategies provide the desired radiotherapy benefit. There are limited publications on the effectiveness of abdominal compression on reducing kidney motion which warrant further investigation in this area.

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Section: Discussionmentioning

confidence: 99%

A Review of Kidney Motion under Free, Deep and Forced-Shallow Breathing Conditions: Implications for Stereotactic Ablative Body Radiotherapy Treatment

Pham

Kron

Foroudi

et al. 2014

Technol Cancer Res Treat

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“…The techniques and technology now available in delivering external-beam radiation, such as stereotactic body radiotherapy, proton radiotherapy, and carbon ion radiotherapy, are establishing its role in the management of HCC (5,7,26). External-beam radiation has some limitations in treating HCC:…”

Section: Discussionmentioning

confidence: 99%

Radiation Segmentectomy: A Novel Approach to Increase Safety and Efficacy of Radioembolization

Riaz

Gates

Atassi

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

219

156

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“…Specifically, tumor cells respond to radiation via multiple growth arrests and a form of protective autophagy (4)(5)(6)(7)(8). Therefore, radiotherapy is rarely used to treat RCC in the clinic (9), and novel anti-tumor agents to reverse the radiosensitivity of RCC are urgently required.…”

Section: Introductionmentioning

confidence: 99%

Ubenimex enhances the radiosensitivity of renal cell carcinoma cells by inducing autophagic cell death

et al. 2016

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Abstract. Renal cell carcinoma (RCC) is resistant to standard radiotherapy. Ubenimex, an aminopeptidase N inhibitor, is widely used as an adjunct therapy after surgery to enhance the function of immunocompetent cells and confer antitumor effects. Our previous study demonstrated that ubenimex induces autophagic cell death in RCC cells. Recently, the molecular mechanism of autophagy induction has been associated with radiosensitivity in RCC cells. In the present study, the ability of ubenimex to enhance RCC cell sensitivity to radiation via the induction of autophagic cell death was determined, and the mechanism of action of this effect was investigated. The 786-O and OS-RC-2 human RCC cell lines were treated with 0.5 mg/ml ubenimex and different doses of irradiation (IR). The cell viability was measured using a colony-formation assay and flow cytometry. Acridine orange (AO)-ethidium bromide (EB) staining was assessed by fluorescence microscopy as an indicator of autophagic cell death. Protein expression was assessed by western blotting. Autophagosomes were evaluated using transmission electron microscopy. RCC cells were used to evaluate the sensitivity to radiation using clonogenic survival and lactate dehydrogenase assays. Furthermore, these parameters were also tested at physiological oxygen levels.

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Carbon Ion Radiation Therapy for Primary Renal Cell Carcinoma: Initial Clinical Experience

Cited by 60 publications

References 21 publications

A Review of Kidney Motion under Free, Deep and Forced-Shallow Breathing Conditions: Implications for Stereotactic Ablative Body Radiotherapy Treatment

A Review of Kidney Motion under Free, Deep and Forced-Shallow Breathing Conditions: Implications for Stereotactic Ablative Body Radiotherapy Treatment

Radiation Segmentectomy: A Novel Approach to Increase Safety and Efficacy of Radioembolization

Ubenimex enhances the radiosensitivity of renal cell carcinoma cells by inducing autophagic cell death

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