Carbon Ion Radiation Therapy With Concurrent Gemcitabine for Patients With Locally Advanced Pancreatic Cancer

Carbon‐ion radiotherapy for isolated para‐aortic lymph node recurrence from colorectal cancer

“…A median total dose of 52.8 Gy(RBE) (range, 48‐52.8 Gy(RBE)) was delivered to the PTV, with a median daily dose of 4.4 Gy(RBE) (range, 4.0‐4.6 Gy(RBE)). We identified that a radiation dose of ≤55.2 Gy(RBE)/12fr was tolerable when treating tumors in the upper abdominal field, such as pancreatic cancer . A fractionation regimen of 52.8 Gy(RBE) in 12 fractions was used for 29 (85%) patients.…”

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

“…Very little is known, however, about the safety and efficacy of combining chemotherapy with C-ions. Combining CIRT with chemotherapy has only been used in a few patient cohorts undergoing CIRT [91,92,93]. Generally, chemotherapy demonstrated additive cytotoxicity when combined with CIRT in in vitro experiments [94,95,96,97,98].…”

“…Gemcitabine was also escalated to 1000 mg/m 2 . The 2-year survival was 48% with excellent tolerability at this dose level [91]. Gastric ulceration was uncommon after CIRT for these patients [169].…”

Comparison of carbon-ion passive and scanning irradiation for pancreatic cancer

“…The dosimetric parameters of gastrointestinal toxicity are controversial, but the dose to the upper gastrointestinal tract in our present study was below the doses reported in these studies. In our institute, Shinoto et al reported that when the dose levels of carbon ion radiotherapy were escalated from 43.2 to 55.2 Gy (RBE) in 12 fractions, only 1 of the 72 treated patients experienced a late grade 3 gastric ulcer and bleeding [13].…”