Carbon ion radiotherapy for recurrent calf myxoid liposarcoma: a case report

Abstract

Liposarcoma (LPS) is the most common soft tissue sarcoma. Myxoid LPS (MLPS) is the second most common subtype of LPS and accounts for 25% to 50% of all LPSs. Like most other soft tissue sarcomas, the mainstay of treatment for LPS is inevitably surgery. Multidisciplinary approaches, including surgery, chemotherapy, and radiotherapy, have been successful in the treatment of LPS during the last three decades. Even so, recurrence of LPS remains challenging. Carbon ion beams produce increased energy deposition at the end of their range to form a Bragg peak while minimizing irradiation damage to surrounding tissues, which facilitates more precise dosage and localization than that achieved with photon beams. Furthermore, carbon ion beams have high relative biologic effectiveness. We herein describe a patient who developed recurrent MLPS in the right calf after two surgeries and underwent carbon ion radiotherapy (CIRT), achieving complete disappearance of the tumor. The patient developed Grade 1 radiation dermatitis 30 days after CIRT, but no other acute toxicities were observed. The tumor had completely disappeared by 120 days after CIRT, and the patient remained disease-free for 27 months after CIRT. The CARE guidelines were followed in the reporting of this case.

Carbon ion radiotherapy with complete tumor regression for primary malignant melanoma of female urethra orifice: a case report

“…We used this facility to treat tumors since November 2018. 24 Few reports worldwide have described patients who underwent CIRT for treatment of PMMFU. In the present case, we treated one patient with CIRT and achieved a good outcome with no adverse events.…”

Carbon ion radiotherapy for recurrent ameloblastoma: A case report

“…WWHIC is affiliated to Wuwei Cancer Hospital, and WWHIC has been officially licensed for clinical use on 1 April 2019. 6 By 5 April 2021, WWHIC has completed CIRT for 303 patients.…”

“…Treatment planning included a biologic treatment plan optimization procedure using the carbon ion Treat Plan (ciTreat, version 1.0, IMP) treatment planning software system which takes into account local values of the RBE calculated by the ciPlan software based on the mixed beam model. 6 Evaluation of efficacy was performed according to the RECSIT 1.1; CTCAE-V5.0 was used to evaluate adverse events. 7 Radiation Therapy Oncology Group (RTOG) acute radiation injury classification criteria were used to evaluate radiation damage.…”

“…7 Radiation Therapy Oncology Group (RTOG) acute radiation injury classification criteria were used to evaluate radiation damage. 6 …”