2018
DOI: 10.1002/cam4.1679
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Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma

Abstract: Carbon ion radiotherapy is known for its high‐precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients’ median age was 54 years, and the median follow‐up period was 49.4 (range 6.4‐146.4) months. The median tumor volume was 356 cm3. The 5‐year local control, overall survival, and disease‐free survival rates were 65%, 46%, and 39%, respectively. In… Show more

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Cited by 43 publications
(38 citation statements)
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“…Presumably, the most appropriate indication for this method is very large tumors occurring in the pelvis, such as sacral chordoma. Recently, several institutions have reported the efficacy of PT in various kinds of bone and soft-tissue sarcoma, including chordoma 17, 20, 21, 22. However, in cases in which the tumor is located adjacent to normal organs, delivering curative doses to the tumor will be difficult even if PT is adapted.…”
Section: Discussionmentioning
confidence: 99%
“…Presumably, the most appropriate indication for this method is very large tumors occurring in the pelvis, such as sacral chordoma. Recently, several institutions have reported the efficacy of PT in various kinds of bone and soft-tissue sarcoma, including chordoma 17, 20, 21, 22. However, in cases in which the tumor is located adjacent to normal organs, delivering curative doses to the tumor will be difficult even if PT is adapted.…”
Section: Discussionmentioning
confidence: 99%
“…Although one third of the patients had already recurrent tumors, they found a remarkable 5-year LC-and OS rates of 69% and 50% with no grade 3+ toxicities with a median follow-up of 36 months. Recently, Imai et al [64] reported the largest series focusing on carbon ion treatment for unresectable localized axial STS. They treated 128 patients with a median dose of 70.4 GyE in 16 fractions and observed a 5-year-LC and OS rates of 65% and 46%.…”
Section: Definitive Rt For Inoperable Primary Tumorsmentioning
confidence: 99%
“…CIRT allowed for relatively high local disease control and satisfactory survival outcomes, with manageable toxicities, as most patients developed only grade ≤ 2 skin acute reactions. In a retrospective analysis by Imai et al (2018), CIRT was shown to allow high irradiation doses with mild toxicity and satisfactory local control in non-resectable axial STS [46]. CIRT may also prove useful in the management of recurrent sarcomas in anatomical localizations hindering surgical access which can result in functional or aesthetic damage, such us the orbit and spermatic cord or pelvis and the spine [47,48].…”
Section: Discussionmentioning
confidence: 99%