Carbon Ions Suppress Angiogenesis and Lung Metastases in Melanoma by Targeting CXCL10
Chengcheng Li,
Qiuning Zhang,
Hongtao Luo
et al.
Abstract:Carbon-ion radiotherapy (CIRT) enhanced local control in patients with malignant melanoma. In several in vitro studies, carbon ions (C ions) have been also shown to decrease the metastatic potential of melanoma cells. CXC motif 10 (CXCL10) has been shown to play a crucial role in regulating tumor metastasis and it significantly increase in human embryonic kidney cells after heavy ion irradiations. This study sought to explore the regulatory effect of C ions on melanoma metastasis, emphasizing the role of CXCL1… Show more
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