Carbon monoxide (CO)-Strengthened cooperative bioreductive anti-tumor therapy via mitochondrial exhaustion and hypoxia induction

Li, Yongjuan; Dang, Juanjuan; Liang, Qiujun; Yin, Lichen

doi:10.1016/j.biomaterials.2019.04.004

Cited by 65 publications

(47 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, tirapazamine (TPZ) is a hypoxia‐responsive activated anticancer drug. It is frequently used in many latest designs of hypoxia‐sensitive platform 126,131,144–146 . In the presence of hypoxia, TPZ undergoes the metabolism of an intracellular reductase to form a highly reactive radical species capable of provoking DNA breaks and chromosomal aberrations, leaving cell structural damage and death 147 .…”

Section: Endogenous‐triggered Smart Materialsmentioning

confidence: 99%

Smart materials for drug delivery and cancer therapy

Yang

Zeng

Huang

et al. 2020

VIEW

127

View full text Add to dashboard Cite

Until now, enormous smart materials have been engineered with endogenous stimulators such as pH, reactive oxygen species, glutathione, hypoxia and enzyme, or exogenous stimulators such as temperature, light, ultrasound, radiation, and magnetic field in drug delivery. As footstone of stimuli‐responsive nanocarriers, endogenous/exogenous responsive smart materials possess many properties, such as responding ability to specific triggers, controlled drug release, long blood circulation, increased tumor accumulation, “ON‐OFF” switch activities, enhanced diagnostic accuracy, and therapeutic efficacy. Smart materials have attracted considerable attention because they provide likelihood strategy for individualized and comprehensive therapy. In this review, significant research achievements of smart materials responsive to different triggers including their synthesis and formulation mechanism, responsive mechanism, applications, multiple functions are summarized and discussed separately. We primarily focus on the studies in the past few years (2017‐2020). The current situation and remaining challenges of stimuli‐sensitive materials‐based nanocarriers for clinical translation are discussed rationally at the end. It is hope that this timely and overall review would provide some helpful information for researchers in this field.

show abstract

Section: Endogenous‐triggered Smart Materialsmentioning

confidence: 99%

Smart materials for drug delivery and cancer therapy

Yang

Zeng

Huang

et al. 2020

VIEW

127

View full text Add to dashboard Cite

show abstract

“…As an endogenous signaling molecule, CO has a variety of biomedical functions, such as regulating blood pressure, reducing inflammation, sensitizing the tumor cells to chemotherapy, and dysfunctionalizing mitochondrial aerobic breathing energy supply [ 134 ]. Based on these functionalities, the study of CO as a therapeutic agent has received widespread attention [ 136 , 137 ]. However, to avoid the toxicity of CO, it is essential to deliver CO specifically to the tumor sites and release the payload on demand.…”

Section: Carbon-containing Reactive Species For Cancer Therapymentioning

confidence: 99%

Section: Carbon-containing Reactive Species For Cancer Therapymentioning

confidence: 99%

“…For example, Yin et al prepared a theranostic nanoplatform by utilizing m-PB NPs as carriers to support the tirapazamine (TPZ) and iron pentacarbonyl (Fe(CO) 5 , CO donor) ( Fig. 10 d) [ 137 ]. The modification of polyallylamine hydrochloride (PAH) and polyacrylic acid (PAA) on the surface prolonged the blood circulation of the nanoplatform and promoted its accumulation in tumor sites.…”

Section: Carbon-containing Reactive Species For Cancer Therapymentioning

confidence: 99%

See 1 more Smart Citation

Photoactivatable nanogenerators of reactive species for cancer therapy

Zheng

Jin

Liu

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

In recent years, reactive species-based cancer therapies have attracted tremendous attention due to their simplicity, controllability, and effectiveness. Herein, we overviewed the state-of-art advance for photo-controlled generation of highly reactive radical species with nanomaterials for cancer therapy. First, we summarized the most widely explored reactive species, such as singlet oxygen, superoxide radical anion (O 2 ●- ), nitric oxide ( ● NO), carbon monoxide, alkyl radicals, and their corresponding secondary reactive species generated by interaction with other biological molecules. Then, we discussed the generating mechanisms of these highly reactive species stimulated by light irradiation, followed by their anticancer effect, and the synergetic principles with other therapeutic modalities. This review might unveil the advantages of reactive species-based therapeutic methodology and encourage the pre-clinical exploration of reactive species-mediated cancer treatments.

show abstract

“…In this case, there are two basic requirements: i) the agent needs to be able to attenuate CP's nephrotoxicity; and ii) the agent must not reduce the efficacy of CP as a chemotherapeutic in treating cancer. With the known ability of CO to inhibit and/or sensitize cancer cells toward chemotherapy, 106,[214][215][216][217][218][219][220][221][222][223][224] including CP-resistant cancer cells, 225 CO delivered in any form represents an attractive agent for this purpose. Motterlini and co-workers reported in 2006 the first study of the protective effects of metal-based CO-RMs in drug-related kidney injury.…”

Section: Author Manuscriptmentioning

confidence: 99%

Carbon monoxide: An emerging therapy for acute kidney injury

Yang

Caestecker

Otterbein

et al. 2019

Medicinal Research Reviews

View full text Add to dashboard Cite

Treating acute kidney injury (AKI) represents an important unmet medical need both in terms of the seriousness of this medical problem and the number of patients. There is also a large untapped market opportunity in treating AKI. Over the years, there has been much effort in search of therapeutics with minimal success. However, over the same time period, new understanding of the underlying pathobiology and molecular mechanisms of kidney injury have undoubtedly helped the search for new therapeutics. Along this line, carbon monoxide (CO) has emerged as a promising therapeutic agent because of its demonstrated cytoprotective, and immunomodulatory effects. CO has also been shown to sensitize cancer, but not normal cells, to chemotherapy. This is particularly important in treating cisplatin-This is the author manuscript accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

show abstract

Carbon monoxide (CO)-Strengthened cooperative bioreductive anti-tumor therapy via mitochondrial exhaustion and hypoxia induction

Cited by 65 publications

References 44 publications

Smart materials for drug delivery and cancer therapy

Smart materials for drug delivery and cancer therapy

Photoactivatable nanogenerators of reactive species for cancer therapy

Carbon monoxide: An emerging therapy for acute kidney injury

Contact Info

Product

Resources

About